Kevin Patrick Mcbride

US Patent:

6512162, Jan 28, 2003

Filed:

Jul 10, 1998

Appl. No.:

09/113244

Inventors:

Kevin E. McBride - Davis CA
Narender Nehra - Chesterfield MO
Douglas A. Russell - Madison WI
David M. Stalker - Woodland CA
Jeffrey M. Staub - Chesterfield MO

Assignee:

Calgene LLC - Davis CA

International Classification:

C12N 1582

US Classification:

800278, 800287, 800288, 435419, 435468, 536 236, 536 237, 536 2372, 536 241, 536 235

Abstract:

Constructs and methods are provided for expressing peptides derived from eukaryotic organisms in plant plastids. Constructs have a promoter functional in a plant plastid, a DNA sequence encoding a peptide derived from an eukaryotic organism and a transcription termination region. Other elements include a selectable marker for selection of plant cells comprising a plastid expressing the marker and DNA regions of homology to the genome of the plastid and optionally a ribosome binding site joined to the promoter. By methods using such constructs high levels of eukaryotic peptides, such as mammalian proteins, are produced in a plant cell by growing plant cells under conditions whereby the DNA encoding sequences re expressed to produce eukaryotic peptide in said plastid.

US Patent:

7344885, Mar 18, 2008

Filed:

Jun 20, 2003

Appl. No.:

10/600230

Inventors:

Jack Q. Wilkinson - Cary NC, US
Kevin McBride - Davis CA, US
Sean Bertain - Piedmont CA, US

Assignee:

Pioneer Hi-Bred International, Inc. - Johnston IA

International Classification:

C12N 15/82

US Classification:

435419, 4353201

Abstract:

The present invention provides recombinant expression cassettes comprising a fungal 3′ termination sequence which is functional in a plant. The recombinant expression cassettes comprise a plant promoter operably linked to a coding sequence having a stop codon, and the fungal 3′ termination sequence. The fungal 3′ termination sequence is heterologous to the coding sequence. The fungal 3′ termination sequence comprises structural features including a cleavage site, a positioning element, and an upstream element. The present invention also comprises methods for construction of the plant expression cassettes and introducing the cassettes into plant cells.

US Patent:

7732678, Jun 8, 2010

Filed:

Dec 3, 1997

Appl. No.:

08/984099

Inventors:

Kevin McBride - Davis CA, US
David M. Stalker - Woodland CA, US
Julie R. Pear - Davis CA, US
Luis Perez-Grau - Davis CA, US

Assignee:

Calgene LLC - Davis CA

International Classification:

A01H 5/00
C07H 21/04
C12N 15/82

US Classification:

800314, 4353201, 435419, 536 232, 536 236, 536 241, 800282

Abstract:

Novel DNA constructs are provided which may be used as molecular probes or inserted into a plant host to provide for modification of transcription of a DNA sequence of interest in cotton fiber, particularly in very early fiber development. The DNA constructs comprise a cotton fiber transcriptional initiation regulatory region associated with a gene which is expressed in cotton fiber.

US Patent:

8580556, Nov 12, 2013

Filed:

Aug 1, 2012

Appl. No.:

13/563854

Inventors:

Kevin E McBride - Davis CA, US
Michael W Lassner - Urbandale IA, US
Loren L Looger - Madison AL, US
Brian McGonigle - Wilmington DE, US

Assignee:

E. I. du Pont de Nemours and Company - Wilmington DE
Pioneer Hi-Bred International Inc. - Johnston IA

International Classification:

C12N 1/20
C07H 21/04

US Classification:

4352523, 536 237, 43525233, 4352528

Abstract:

Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.

US Patent:

20010014977, Aug 16, 2001

Filed:

Feb 5, 2001

Appl. No.:

09/777347

Inventors:

Kevin McBride - Davis CA, US
David Stalker - Davis CA, US

International Classification:

A01H001/00
A01H005/00
C07H021/04
C12N015/82
C12N015/87

US Classification:

800/282000, 536/023200, 435/419000, 800/314000

Abstract:

Novel DNA constructs are provided which may be used as molecular probes or inserted into a plant host to provide for modification of transcription of a DNA sequence of interest in ovary tissue, particularly in very early fruit development. The DNA constructs comprise a transcriptional initiation regulatory region associated with gene expression in ovary tissue from immediately prior to anthesis through flower senescence.

US Patent:

20020182593, Dec 5, 2002

Filed:

Oct 30, 2001

Appl. No.:

10/020540

Inventors:

Gusui Wu - Davis CA, US
Kevin McBride - Davis CA, US

Assignee:

Maxygen, Inc. - Redwood City CA

International Classification:

C12Q001/70
C07H021/04
A01H001/00
C12N005/04
A01H005/00

US Classification:

435/005000, 800/280000, 435/320100, 435/419000, 536/023600

Abstract:

The present invention provides promoters for driving the expression of heterologous polynucleotide sequences in plant cells. The promoters are derived from strawberry vein banding virus (SVBV), and include variants, derivatives, fragments, and modified versions of the naturally occurring promoter sequences. The present invention also provides expression cassettes comprising the promoters, as well as methods of using the promoters to drive gene expression in plant cells and transgenic plants.

US Patent:

20030106089, Jun 5, 2003

Filed:

Oct 31, 2002

Appl. No.:

10/285649

Inventors:

Kevin McBride - Davis CA, US
David Stalker - Woodland CA, US
Julie Pear - Davis CA, US
Luis Perez-Grau - Davis CA, US

International Classification:

A01H005/00
C12N015/82
C07H021/04
C12N009/06
C12N005/04

US Classification:

800/278000, 536/023200, 435/069100, 435/191000, 435/320100, 435/419000, 800/314000

Abstract:

Novel DNA constructs are provided which may be used as molecular probes or inserted into a plant host to provide for modification of transcription of a DNA sequence of interest in cotton fiber, particularly in very early fiber development. The DNA constructs comprise a cotton fiber transcriptional initiation regulatory region associated with a gene which is expressed in cotton fiber.

US Patent:

58664211, Feb 2, 1999

Filed:

Jan 29, 1996

Appl. No.:

8/593205

Inventors:

Kevin E. McBride - Davis CA
David M. Stalker - Davis CA

Assignee:

Calgene LLC - Davis CA

International Classification:

C12N 514
C12N 1582

US Classification:

435419

Abstract:

Novel compositions and methods useful for genetic engineering of plant cells to provide increased expression in the plastids of a plant or plant cell of a protein which produces a phenotype which is present when the plant or plant cell is grown in the absence of means for selecting transformed cells. Expression of the Bacillus thuringiensis bacterial protoxin in a plant chloroplast is exemplified.