Kimberly A Ferguson

US Patent:

6781028, Aug 24, 2004

Filed:

Jun 14, 1999

Appl. No.:

09/332522

Inventors:

Michael R. Costa - San Francisco CA
Stephen K. Doberstein - San Francisco CA
Sarah L. Elson - San Francisco CA
Kimberly Carr Ferguson - Burlingame CA
Sheila Akiko Homburger - Oakland CA

Assignee:

Exelixis, Inc. - South San Francisco CA

International Classification:

G01N 3300

US Classification:

800 3, 800 13, 4353201, 435325, 536 231

Abstract:

and that have been genetically modified to express or mis-express proteins involved in the sterol regulatory element binding protein (SREBP) pathway are described. These genetically modified animal models have identifiable phenotypes that make them useful in assays for studying lipid metabolism, other genes implicated in lipid metabolism, and compounds capable of modulating lipid metabolism pathways. Methods for studying lipid metabolism in living nematodes using fluorescently-labelled fatty acid conjugates, such BODITYâ fatty acid conjugates, are also described. Novel SREBP pathway nucleic acid and protein sequences are also described.

US Patent:

20030187246, Oct 2, 2003

Filed:

Jan 9, 2003

Appl. No.:

10/339740

Inventors:

Stephen Doberstein - San Francisco CA, US
Andrew Buchman - Berkeley CA, US
Kimberly Ferguson - Pacifica CA, US
Sheila Homburger - Oakland CA, US
Darren Platt - San Francisco CA, US

International Classification:

C12Q001/68
A01K067/033
C07H021/04
C07K005/00
C12P021/02
C07K014/62
C12N015/85

US Classification:

536/023500, 530/303000, 435/069100, 435/320100, 435/325000, 435/006000, 435/455000, 800/008000, 530/388250

Abstract:

The present invention relates to insulin-like genes and methods for identifying insulin-like genes. The methods provide nucleotide sequences of insulin-like genes, amino acid sequences of their encoded proteins, and derivatives (e.g., fragments) and analogs thereof. The invention further relates to fragments (and derivatives and analogs thereof) of insulin-like proteins which comprise one or more domains of an insulin-like protein. Antibodies to an insulin-like protein, and derivatives and analogs thereof, are provided. Methods of production of an insulin-like protein (e.g., by recombinant means), and derivatives and analogs thereof, are provided. Further, methods to identify the biological function of a insulin-like gene are provided, including various methods for the functional modification (e.g., overexpression, underexpression, mutation, knock-out) of one or more genes simultaneously. Still further, methods to identify a gene which modifies the function of, and/or functions in a downstream pathway from, an insulin-like gene are provided.

US Patent:

20100112566, May 6, 2010

Filed:

Sep 24, 2007

Appl. No.:

12/442372

Inventors:

Kyle A. Edgar - Berkeley CA, US
Kimberly Carr Ferguson - El Granada CA, US
Monique Nicoll - El Granada CA, US
Christopher G. Winter - Needham MA, US

International Classification:

C12Q 1/68
G01N 33/53

US Classification:

435 6, 435 72

Abstract:

Human VIPR1 genes are identified as modulators of the E2F/RB pathway, and thus are therapeutic targets for disorders associated with defective E2F/RB function. Methods for identifying modulators of E2F/RB, comprising screening for agents that modulate the activity of VIPR1 are provided.

US Patent:

6627746, Sep 30, 2003

Filed:

May 26, 1998

Appl. No.:

09/084303

Inventors:

Stephen Kohl Doberstein - San Francisco CA
Darren Mark Platt - San Francisco CA
Kimberly Carr Ferguson - Pacifica CA
Andrew Roy Buchman - Berkeley CA
Sheila Akiko Homburger - Oakland CA

Assignee:

Exelixis, Inc. - South San Francesco CA

International Classification:

C07H 2104

US Classification:

536 235, 536 231, 530303, 530350, 435 691

Abstract:

The present invention relates to insulin-like genes and methods for identifying insulin-like genes. The methods provide nucleotide sequences of insulin-like genes, amino acid sequences of their encoded proteins, and derivatives (e. g. , fragments) and analogs thereof. The invention further relates to fragments (and derivatives and analogs thereof) of insulin-like proteins which comprise one or more domains of an insulin-like protein. Antibodies to an insulin-like protein, and derivatives and analogs thereof, are provided. Methods of production of an insulin-like protein (e. g. , by recombinant means), and derivatives and analogs thereof, are provided. Further, methods to identify the biological function of a insulin-like gene are provided, including various methods for the functional modification (e. g. , overexpression, underexpression, mutation, knock-out) of one or more genes simultaneously. Still further, methods to identify a gene which modifies the function of, and/or functions in a downstream pathway from, an insulin-like gene are provided.

US Patent:

20060088829, Apr 27, 2006

Filed:

Feb 5, 2003

Appl. No.:

10/504120

Inventors:

Arthur Brace - Redwood City CA, US
Agnes Eliares - South San Francisco CA, US
Kimberly Ferguson - Elgranada CA, US
Felipa Mapa - Somerville MA, US
Donald Ruhrmund - San Francisco CA, US
Jianfeng Wu - San Francisco CA, US

International Classification:

C12Q 1/68
G01N 33/53

US Classification:

435006000, 435007100

Abstract:

Human MINR genes are identified as modulators of INR signaling and thus are therapeutic targets for disorders associated with defective INR signaling. Methods for identifying modulators of MINR, comprising screening for agents that modulate the activity of MINR are provided.