Claude Benedict - Cambridge MA, US John Diener - Cambridge MA, US David Epstein - Belmont MA, US Dilara Grate - Cambridge MA, US Sara Chesworth Keene - Tewksbury MA, US Jeffrey Kurz - Arlington MA, US Markus Kurz - Newton MA, US Thomas Greene McCauley - Cambridge MA, US James Rottman - Sudbury MA, US Kristin Thompson - Arlington MA, US Charles Wilson - Concord MA, US Anna J. Zoltoski - South Boston MA, US
Assignee:
Archemix Corp. - Cambridge MA
International Classification:
C07H 21/04
US Classification:
536 245
Abstract:
The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
Materials And Methods For The Generation Of Transcripts Comprising Modified Nucleotides
John L. Diener - Cambridge MA, US Anthony Dominic Keefe - Cambridge MA, US Kristin Thompson - Arlington MA, US Chunhua Wang - Acton MA, US Shuhao Zhu - Lincoln MA, US
Assignee:
Archemix Corp. - Cambridge MA
International Classification:
C12N 9/12
US Classification:
435194, 435183, 435 691
Abstract:
Materials and methods are provided for producing aptamer therapeutics having fully modified nucleotide triphosphates incorporated into their sequence.
Gene Knock-Down By Intracellular Expression Of Aptamers
David Epstein - Belmont MA, US Harold Marsh - Charlestown MA, US Shannon Pendergrast - Cambridge MA, US Kristin Thompson - Arlington MA, US
International Classification:
C12Q001/68 C07H021/02 A61K048/00
US Classification:
435006000, 514044000, 536023100
Abstract:
Materials and methods are provided for target validation by gene knock-down with intracellularly expressed aptamers and siRNAs. The aptamers produced by the materials and methods of the invention are useful in target validation for therapeutics development.
Controlled Modulation Of The Pharmacokinetics And Biodistribution Of Aptamer Therapeutics
Judith Healy - Lexington MA, US Markus Kurz - Newton MA, US Thomas McCauley - Cambridge MA, US Kristin Thompson - Arlington MA, US Charles Wilson - Concord MA, US Dorothy Margolskee - Upper Montclair NJ, US
International Classification:
A61K 48/00 A61K 9/14
US Classification:
514044000, 424486000
Abstract:
Materials and methods are provided to modulate, in a controlled manner, the pharmacokinetic and biodistribution properties of nucleic acid aptamers, and to enhance their safety and efficacy properties as therapeutic agents.
Aptamer Therapeutics Useful In The Treatment Of Complement-Related Disorders
Claude Benedict - Cambridge MA, US John Diener - Cambridge MA, US David Epstein - Belmont MA, US Dilara Grate - Cambridge MA, US Sara Keene - Tewksbury MA, US Jeffrey Kurz - Arlington MA, US Markus Kurz - Newton MA, US Thomas McCauley - Cambridge MA, US James Rottman - Sudbury MA, US Kristin Thompson - Arlington MA, US Charles Wilson - Concord MA, US Anna Zoltoski - South Boston MA, US
International Classification:
A61K 48/00 C12Q 1/68 C07H 21/02
US Classification:
514044000, 536023100, 435006000
Abstract:
The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
Aptamers To The Human Il-12 Cytokine Family And Their Use As Autoimmune Disease Therapeutics
John Diener - Cambridge MA, US David Epstein - Belmont MA, US Alicia Ferguson - Somerville MA, US Nobuko Hamaguchi - Framingham MA, US Shannon Pendergrast - Cambridge MA, US Pooja Sawhney - Arlington MA, US Kristin Thompson - Arlington MA, US
The present invention provides materials and methods to treat immune disease in which cytokines are involved in pathogenesis. The materials and methods of the present invention are useful in the treatment of autoimmune diseases. The materials and methods of the present invention are directed to nucleic acid ligands capable of binding to human IL-23 and/or human IL-12 cytokines and thus modulate their biological activity and are useful as therapeutic agents in immune, auto-immune and cancer therapeutics.
Aptamers To The Human Il-12 Cytokine Family And Their Use As Autoimmune Disease Therapeutics
John Diener - Cambridge MA, US Alicia Ferguson - Somerville MA, US Nobuko Hamaguchi - Framingham MA, US Sara Keene - Tewksbury MA, US Pooja Sawhney - Arlington MA, US Kristin Thompson - Arlington MA, US
International Classification:
A61K 48/00 C07H 21/04
US Classification:
514044000, 536023500
Abstract:
The present invention provides materials and methods to treat immune disease in which cytokines are involved in pathogenesis. The materials and methods of the present invention are useful in the treatment of autoimmune diseases. The materials and methods of the present invention are directed to nucleic acid ligands capable of binding to human IL-23 and/or human IL-12 cytokines and thus modulate their biological activity and are useful as therapeutic agents in immune, auto-immune and cancer therapeutics.
Dr. Thompson graduated from the Ohio State University College of Medicine in 1996. She works in Dublin, OH and specializes in Internal Medicine and Adolescent Medicine. Dr. Thompson is affiliated with Ohio State University Wexner Medical Center.
University of Illinois at Urbana-Champaign - Mathematics
Tagline:
....come back to me
Kristin Thompson
Education:
University of Texas at Austin - Civil Engineering
Kristin Thompson
Education:
University of Montana - Missoula - Speech and Language Pathology
Kristin Thompson
Work:
My house - Full time mommy and wife
Kristin Thompson
About:
My name is Kristin, and I am a college junior in my 20s. I go to Villanova University, and am a sister of Alpha Gamma Delta. Crumbs and Curls is about beauty, fashion, baking, and crafting through the...