Lian Ying Li

US Patent:

20220249682, Aug 11, 2022

Filed:

Oct 16, 2020

Appl. No.:

17/754915

Inventors:

- Salt Lake City UT, US
Lian LI - Salt Lake City UT, US
C. Matthew PETERSON - Bountiful UT, US
Jindrich KOPECEK - Salt Lake City UT, US

International Classification:

A61K 47/68
A61P 35/00

Abstract:

Described herein are biodegradable drug delivery conjugates and anti-cancer conjugates for effectively delivering anti-cancer agents to a subject. The conjugates include a single first cleavable peptide linker covalently connected to two polymeric segments, wherein at least one PD-L1 inhibitor is covalently bonded to each polymeric segment (referred to herein as “a PD-L1 inhibitor polymer conjugate”). Also described herein is the use of the PD-L1 inhibitor polymer conjugates in combination with anticancer agents to treat or prevent cancer.