- Salt Lake City UT, US Lian LI - Salt Lake City UT, US C. Matthew PETERSON - Bountiful UT, US Jindrich KOPECEK - Salt Lake City UT, US
International Classification:
A61K 47/68 A61P 35/00
Abstract:
Described herein are biodegradable drug delivery conjugates and anti-cancer conjugates for effectively delivering anti-cancer agents to a subject. The conjugates include a single first cleavable peptide linker covalently connected to two polymeric segments, wherein at least one PD-L1 inhibitor is covalently bonded to each polymeric segment (referred to herein as “a PD-L1 inhibitor polymer conjugate”). Also described herein is the use of the PD-L1 inhibitor polymer conjugates in combination with anticancer agents to treat or prevent cancer.