Mary Beth Monroe

US Patent:

20220211913, Jul 7, 2022

Filed:

Apr 30, 2020

Appl. No.:

17/606657

Inventors:

Mary Beth Monroe - Syracuse NY, US

Assignee:

SYRACUSE UNIVERSITY - SYRACUSE NY

International Classification:

A61L 27/52
A61L 27/48
A61L 27/56
A61L 27/58
A61L 27/54

Abstract:

A shape memory polymer hydrogel that is biodegradable, includes antimicrobial agents, and has a tunable drug delivery is used for wound healing internally and externally. The shape memory polymer is synthesized using a combination of hydrophilic precursors that are configured to have two to four functional end groups, with at least one component that has at least three functional groups. The synthesis route provides for a covalently crosslinked thermoset hydrogel. The chemistry can be tuned to provide desired transition temperatures for delivery (e.g. below 37 C.) and desired pore sizes for healing (e.g. 250-500 μm).

US Patent:

20170327562, Nov 16, 2017

Filed:

Aug 2, 2017

Appl. No.:

15/666709

Inventors:

- College Station TX, US
Magnus Hook - Houston TX, US
Mariah S. Hahn - College Station TX, US
Elizabeth M. Cosgriff-Hernandez - College Station TX, US
Neungseon Seo - Carmel IN, US
Marvin Xuejun Xu - Missouri City TX, US
Jose J. Rivera - Humble TX, US
Mary Beth Monroe - Houston TX, US

International Classification:

C07K 14/78
A61L 33/06
A61L 26/00
A61L 26/00
A61L 26/00
A61L 33/00
A61L 27/48
A61L 27/50
A61L 27/52
A61L 27/54
A61L 26/00
C08G 65/333
A61L 27/26

Abstract:

The present disclosure provides synthetic collagen and methods of making and using synthetic collagen that include a synthetic collagen that facilitates wound closure comprising an isolated and purified triple helical backbone protein that facilitates wound closure comprising one or more alteration in a triple helical backbone protein sequence, that stabilize the isolated and purified triple helical backbone protein and does not disrupt an additional collagen ligand interaction; and one or more integrin binding motifs, wherein the isolated and purified triple helical backbone protein facilitates wound closure.

Address:

3310 Fallen Leaf, San Antonio, TX 78230

VIN:

5GZCZ33D07S827464

Make:

SATURN

Model:

VUE

Year:

2007