Bankruptcy Civil Rights Corporate Family Law Domestic Relations Health Care Insurance Law Personal Injury Law Product Liability Law Real Property Law Social Security Law Trust Taxation Law Administrative Law/Regulatory Law Business Law Commercial Law Probate & Estate Planning Government Relations & Advisory Tax Commercial Public and Public Finance
The present invention is concerned with isoxazole-pyrazoles of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as therapeutics. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
The present invention is concerned with isoxazole-isoxazoles and isoxazole-isothiazoles of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as cognitive enhancers or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
The present invention is concerned with isoxazole-thiazole derivatives of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
Bernd Buettelmann - Schopfheim, DE Roland Jakob-Roetne - Inzlingen, DE Henner Knust - Rheinfelden, DE Matthew C. Lucas - Verona NJ, US Andrew Thomas - Binningen, CH
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
International Classification:
A61K 31/4427 C07D 413/12
US Classification:
514340, 5462681, 5462684, 5462721, 514336
Abstract:
The present invention is concerned with novel isoxazoles of formula I.
Isoxazoles / O-Pyridines With Ethyl And Ethenyl Linker
Matthew C. Lucas - Verona NJ, US Andrew Thomas - Binningen, CH
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ Roche Palo Alto LLC - Palo Alto CA
International Classification:
A61K 31/501 C07D 413/12 C07D 413/14
US Classification:
51425201, 544238
Abstract:
The present invention is concerned with isoxazole-pyridazines of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
Roland Jakob-Roetne - Inzlingen, DE Matthew C. Lucas - Verona NJ, US Andrew Thomas - Binningen, CH
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ Roche Palo Alto LLC - Palo Alto CA
International Classification:
A61K 31/443 C07D 413/14
US Classification:
514333, 546256
Abstract:
The present invention is concerned with isoxazole-pyridines of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as pharmaceuticals. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
Name / Title
Company / Classification
Phones & Addresses
Matthew Lucas President
Lucas Electric Co Inc Legal Services
415 Mercer St, New York, NY 10019
Matthew Lucas President
Lucas Electric Co Inc
415 Mercer St, New York, NY 10019 (609)4485218, (212)8395999
Microsoft Office Weld Natural Gas Pipelines Gas Engineering Onshore Inspection Ndt Refinery Petroleum Piping Metal Fabrication Oil/Gas Welding Upstream Construction Safety Supervisory Skills Corrosion Asme Certified Welding Inspector Petrochemical Energy Construction Epc Factory Oil and Gas Industry Offshore Drilling Completion Pressure Vessels Lng Pressure Subsea Engineering Energy Industry Fpso Commissioning Valves Drilling Boilers Tanks Safety Management Systems Project Engineering Project Control Refineries Oil