Michael Joseph Pennington

US Patent:

7723063, May 25, 2010

Filed:

Apr 28, 2005

Appl. No.:

11/119293

Inventors:

Xavier Lauth - San Diego CA, US
Mark E. Westerman - San Diego CA, US
Vaughn E. Ostland - La Quinta CA, US
Jason A. Stannard - San Diego CA, US
Michael W. Pennington - Mount Laurel NJ, US

Assignee:

Intrinsic Lifesciences - La Jolla CA

International Classification:

G01N 33/00
G01N 33/53
G01N 33/543
C07K 14/00

US Classification:

435 793, 435 71, 435 75, 436 86, 436518, 530324

Abstract:

The present invention concerns a method for the oxidative refolding of a hepcidin polypeptide to a form that is mature, bioactive and folded as in the native configuration and molecular mass; a method for measuring the level of native, bioactive hepcidin in a vertebrate animal; a method for measuring the level of hepcidin gene expression in a vertebrate animal; and a method for regulating the production of native, bioactive hepcidin in a vertebrate animal in vivo. The present invention also concerns an antibody or fragment thereof that specifically binds to a continuous, discontinuous, and/or conformational epitope of a mature and bioactive hepcidin folded as in the native configuration; and a pharmaceutical composition that includes the antibody or a hepcidin polypeptide and that provides antimicrobial, agonistic, or antagonistic activities in vivo in a vertebrate animal.

US Patent:

7745162, Jun 29, 2010

Filed:

Nov 11, 2008

Appl. No.:

12/268964

Inventors:

Xavier Lauth - San Diego CA, US
Mark E. Westerman - San Diego CA, US
Vaughn E. Ostland - La Quinta CA, US
Jason A. Stannard - San Diego CA, US
Michael W. Pennington - Mount Laurel NJ, US

Assignee:

Intrinsic Lifesciences - La Jolla CA

International Classification:

G01N 33/00
G01N 33/53
G01N 33/543
C07K 14/00

US Classification:

435 793, 435 71, 435 75, 436 86, 436518, 530324

Abstract:

The invention provides compositions and methods for measuring human serum hepcidin levels. The invention provides methods for the oxidative refolding of a hepcidin polypeptide to a form that is mature, bioactive and folded as in the native configuration and molecular mass; a method for measuring the level of native, bioactive hepcidin in a vertebrate animal.

US Patent:

20110183362, Jul 28, 2011

Filed:

Jun 10, 2010

Appl. No.:

12/797797

Inventors:

Xavier LAUTH - San Diego CA, US
Mark E. WESTERMAN - San Diego CA, US
Vaughn E. OSTLAND - La Quinta CA, US
Jason A. STANNARD - San Diego CA, US
Michael W. PENNINGTON - Cherry Hill NJ, US

Assignee:

INTRINSIC LIFESCIENCES LLC - La Jolla CA

International Classification:

G01N 33/74
C07K 14/575
C12N 9/96

US Classification:

435 792, 530324, 435188

Abstract:

The invention provides compositions and methods for measuring human serum hepcidin levels. The invention provides methods for the oxidative refolding of a hepcidin polypeptide to a form that is mature, bioactive and folded as in the native configuration and molecular mass; a method for measuring the level of native, bioactive hepcidin in a vertebrate animal.

US Patent:

20120202229, Aug 9, 2012

Filed:

Feb 2, 2012

Appl. No.:

13/364979

Inventors:

Xavier LAUTH - San Diego CA, US
Mark E. WESTERMAN - San Diego CA, US
Vaughn E. OSTLAND - La Quinta CA, US
Jason A. STANNARD - San Diego CA, US
Michael W. PENNINGTON - Cherry Hill NJ, US

Assignee:

INTRINSIC LIFESCIENCES LLC - La Jolla CA

International Classification:

G01N 33/566
C07K 14/47

US Classification:

435 793, 530324

Abstract:

The invention provides compositions and methods for measuring human serum hepcidin levels. The invention provides methods for the oxidative refolding of a hepcidin polypeptide to a form that is mature, bioactive and folded as in the native configuration and molecular mass; a method for measuring the level of native, bioactive hepcidin in a vertebrate animal.

US Patent:

20170368403, Dec 28, 2017

Filed:

Jun 23, 2016

Appl. No.:

15/191521

Inventors:

Michael J. Pennington - Chula Vista CA, US

International Classification:

A63B 21/072
A63B 21/00
A63B 21/062
A63B 21/075
A63B 23/04
A63B 23/02

Abstract:

The embodiments herein relate to an exercise machine for training the muscles of the whole body while specifically targeting the muscles of the legs and back. Specifically, the embodiments herein relate to a Reverse Deadlift Apparatus which allows a trainee to mimic a barbell type deadlift exercise in a safer and more productive fashion. An additional benefit is that the Reverse Deadlift Apparatus encourages a lifter to use proper technique by requiring them to use more of their legs and less of their lower back during the lift. The result of using the Reverse Deadlift Apparatus on a regular basis is that a lifter will increase the strength and power of the muscles of the whole body and specifically will make improvements in the lower body. The added strength and power, along with optimized Deadlifting form, will help a lifter improve their performance in the actual barbell deadlift itself and in any sports requiring a strength or power component (e.g. Football, Baseball, Martial Arts, Wrestling, Powerlifting, Olympic Lifting, Tennis, etc.).