Michael C Weingarten

US Patent:

20110124987, May 26, 2011

Filed:

Apr 21, 2009

Appl. No.:

12/937590

Inventors:

Elisabeth S. Papazoglou - Yardley PA, US
Michael S. Weingarten - Penn Valley PA, US
Leonid Zubkov - Philadelphia, PA
Michael T. Neidrauer - Drexel Hill PA, US
Linda Zhu - Newtown PA, US
Kambiz Pourrezaei - Gladwyne PA, US

International Classification:

A61B 5/1455

US Classification:

600310

Abstract:

Optical changes of tissue during wound healing measured by Near Infrared and Diffuse Reflectance Spectroscopy are shown to correlate with histologic changes. Near Infrared absorption coefficient correlated with blood vessel in-growth over time, while Diffuse Reflectance Spectroscopy (DRS) data correlated with collagen concentration. Changes of optical properties of wound tissue at greater depths are also quantified by Diffuse Photon Density Wave (DPDW) methodology at near infrared wavelengths. The diffusion equation for semi-infinite media is used to calculate the absorption and scattering coefficients based on measurements of phase and amplitude with a frequency domain or time domain device. An increase in the absorption and scattering coefficients and a decrease in blood saturation of the wounds compared to the non wounded sites was observed. The changes correlated with the healing stage of the wound. The methodologies used to collect information regarding the healing state of a wound may be used to clinically assess the efficacy of wound healing agents in a patient (e.g., a diabetic) and as a non-invasive method