Ming Jing Yang

US Patent:

20130095481, Apr 18, 2013

Filed:

Feb 11, 2011

Appl. No.:

13/574001

Inventors:

Philip W. Kantoff - Needham MA, US
Ming Yang - Boston MA, US
Tong Sun - Boston MA, US
Wanling Xie - Chestnut Hill MA, US

Assignee:

DANA-FARBER CANCER INSTITUTE, INC. - Boston MA

International Classification:

C12Q 1/68

US Classification:

435 611

Abstract:

The disclosure provides materials and methods related to using biomarkers for prediction of duration of response to prostate cancer treatment and for treating prostate cancer.

US Patent:

20130323179, Dec 5, 2013

Filed:

May 3, 2013

Appl. No.:

13/886493

Inventors:

Elizabeth M. Enlow - Waltham MA, US
James Bourassa - Somerville MA, US
Colin R. Gardner - Concord MA, US
Hongming Chen - Belmont MA, US
Laura M. Ensign - Towson MD, US
Samuel K. Lai - Carrboro NC, US
Tao Yu - Baltimore MD, US
Justin Hanes - Baltimore MD, US
Ming Yang - Towson MD, US

Assignee:

Johns Hopkins University, The - Baltimore MD

International Classification:

A61K 9/50
A61K 31/56
A61K 31/341
A61K 31/496
A61K 31/675
A61K 31/58
A61K 31/405
A61K 31/12
A61K 31/409
A61K 49/00
A61K 31/573

US Classification:

424 96, 424497, 514180, 514471, 51425407, 514179, 514174, 514420, 514679, 514410, 514 86

Abstract:

Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

US Patent:

20210128483, May 6, 2021

Filed:

Jul 8, 2020

Appl. No.:

16/923980

Inventors:

- Baltimore MD, US
Elizabeth M. Enlow - Waltham MA, US
James Bourassa - Somerville MA, US
Colin R. Gardner - Concord MA, US
Hongming Chen - Belmont MA, US
Laura M. Ensign - Towson MD, US
Samuel K. Lai - Carrboro NC, US
Tao Yu - Baltimore MD, US
Justin Hanes - Baltimore MD, US
Ming Yang - Towson MD, US

International Classification:

A61K 9/50
A61K 47/34
A61K 9/10
A61K 9/51
A61K 31/12
A61K 31/341
A61K 31/405
A61K 31/409
A61K 31/496
A61K 31/56
A61K 31/573
A61K 31/58
A61K 31/675
A61K 49/00
A61K 31/569
A61K 31/635
A61K 31/662
A61K 31/522

Abstract:

Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

US Patent:

20190284634, Sep 19, 2019

Filed:

Mar 12, 2019

Appl. No.:

16/299955

Inventors:

- Boston MA, US
Ming Yang - Boston MA, US
Tong Sun - Newton MA, US
Wanling Xie - Newton MA, US

International Classification:

C12Q 1/6886

Abstract:

The disclosure provides materials and methods related to using biomarkers for prediction of duration of response to prostate cancer treatment and for treating prostate cancer.

US Patent:

20180256508, Sep 13, 2018

Filed:

May 10, 2018

Appl. No.:

15/976736

Inventors:

- Baltimore MD, US
Elizabeth M. Enlow - Waltham MA, US
James Bourassa - Somerville MA, US
Colin R. Gardner - Concord MA, US
Hongming Chen - Belmont MA, US
Laura M. Ensign - Towson MD, US
Samuel K. Lai - Carrboro NC, US
Tao Yu - Baltimore MD, US
Justin Hanes - Baltimore MD, US
Ming Yang - Towson MD, US

International Classification:

A61K 9/50
A61K 31/58
A61K 31/675
A61K 31/409
A61K 31/12
A61K 31/405
A61K 31/573
A61K 31/496
A61K 31/635
A61K 31/56
A61K 31/522

Abstract:

Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

US Patent:

20170266120, Sep 21, 2017

Filed:

Jun 7, 2017

Appl. No.:

15/616799

Inventors:

- Baltimore MD, US
Elizabeth M. Enlow - Waltham MA, US
James Bourassa - Somerville MA, US
Colin R. Gardner - Concord MA, US
Hongming Chen - Belmont MA, US
Laura M. Ensign - Towson MD, US
Samuel K. Lai - Carrboro NC, US
Tao Yu - Baltimore MD, US
Justin Hanes - Baltimore MD, US
Ming Yang - Towson MD, US

International Classification:

A61K 9/50
A61K 31/635
A61K 31/496
A61K 31/573
A61K 31/58
A61K 31/405
A61K 31/12
A61K 31/409
A61K 31/675
A61K 31/56
A61K 31/522

Abstract:

Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

US Patent:

20170128378, May 11, 2017

Filed:

Nov 17, 2016

Appl. No.:

15/354704

Inventors:

- Waltham MA, US
- Baltimore MD, US
James Bourassa - Somerville MA, US
Colin R. Gardner - Concord MA, US
Hongming Chen - Belmont MA, US
Laura M. Ensign - Towson MD, US
Samuel K. Lai - Carrboro NC, US
Tao Yu - Baltimore MD, US
Justin Hanes - Baltimore MD, US
Ming Yang - Towson MD, US

International Classification:

A61K 9/50
A61K 31/635
A61K 31/496
A61K 31/573
A61K 31/522
A61K 31/405
A61K 31/12
A61K 31/409
A61K 31/675
A61K 31/56
A61K 31/58

Abstract:

Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

US Patent:

20160287526, Oct 6, 2016

Filed:

Jun 20, 2016

Appl. No.:

15/187552

Inventors:

- Waltham MA, US
- Baltimore MD, US
James Bourassa - Somerville MA, US
Colin R. Gardner - Concord MA, US
Hongming Chen - Belmont MA, US
Laura M. Ensign - Towson MD, US
Samuel K. Lai - Carrboro NC, US
Tao Yu - Baltimore MD, US
Justin Hanes - Baltimore MD, US
Ming Yang - Towson MD, US

International Classification:

A61K 9/50
A61K 31/341
A61K 31/496
A61K 31/573
A61K 31/675
A61K 31/58
A61K 31/405
A61K 31/12
A61K 31/409
A61K 31/569
A61K 31/56

Abstract:

Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.