Mohamed A Ibrahim

US Patent:

20110288076, Nov 24, 2011

Filed:

Oct 16, 2009

Appl. No.:

13/124604

Inventors:

Mohamed Abdulkader Ibrahim - Mountain View CA, US
Joon Won Jeong - Belmont CA, US
Henry William Beecroft Johnson - San Bruno CA, US
Patrick Kearney - San Francisco CA, US
James W. Leahy - San Leandro CA, US
Gary L. Lewis - San Francisco CA, US
Robin Tammie Noguchi - San Bruno CA, US
John M. Nuss - Danville CA, US

Assignee:

EXELIXIS, INC. - South San Francisco CA

International Classification:

A61K 31/4196
C07D 403/06
C07C 237/22
C07D 307/54
C07D 207/452
C07D 213/56
C07D 403/04
C07D 417/06
C07D 223/04
A61K 31/417
A61K 31/4192
A61K 31/167
A61K 31/341
A61K 31/4015
A61K 31/455
A61K 31/506
A61K 31/541
A61K 31/55
A61P 35/00
A61P 35/02
C07D 277/30

US Classification:

51421712, 548204, 548255, 5482676, 5482656, 564158, 549488, 548546, 546316, 546298, 544295, 544 585, 540610, 514400, 514422, 514383, 514616, 514471, 514425, 514355, 514350, 51425214, 5142278

Abstract:

This disclosure relates to sphingosine-1-phosphate (S1P) receptor antagonists, compositions comprising the S1P receptor antagonists and methods for using and processes for making the S1P receptor antagonists. In particularly, this disclosure relates to sphingosine-1-phosphate 1 (S1P1) receptor antagonists, compositions comprising the S1P1 receptor antagonist and methods for using the S1P1 receptor antagonist, such as in the treatment of cancer, and processes for making the S1P1 receptor antagonists.

US Patent:

20090298830, Dec 3, 2009

Filed:

Jan 30, 2007

Appl. No.:

11/992224

Inventors:

Grace Mann - San Mateo CA, US
Naing Aay - San Mateo CA, US
Arlyn Arcalas - South San Francisco CA, US
S. David Brown - San Carlos CA, US
Wai Ki Vicky Chan - San Francisco CA, US
Jeff Chen - San Francisco CA, US
Hongwang Du - Millbrae CA, US
Sergey Epshteyn - Fremont CA, US
Timothy Patrick Forsyth - Hayward CA, US
Adam A. Galan - Alameda CA, US
Tai Phat Huynh - New York City NY, US
Mohamed Abdulkader Ibrahim - Mountain View CA, US
Henry William Beecroft Johnson - San Bruno CA, US
Brian Kane - Lynchburg VA, US
Patrick Kearney - San Francisco CA, US
Byung Gyu Kim - San Mateo CA, US
Elena S. Koltun - Foster City CA, US
James W. Leahy - San Leandro CA, US
Matthew Sangyup Lee - San Bruno CA, US
Gary L. Lewis - San Francisco CA, US
Lisa E. Meyr - Seattle WA, US
Robin Tammie Noguchi - San Bruno CA, US
Michael Pack - San Francisco CA, US
Brian Hugh Ridgway - Belmont CA, US
Xian Shi - San Bruno CA, US
John Woolfrey - Los Altos CA, US
Peiwen Zhou - Palo Alto CA, US

Assignee:

Exelixis, Inc. - South San Francisco CA

International Classification:

A61K 31/5377
C07D 413/14
A61P 7/00

US Classification:

5142358, 544122

Abstract:

This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R, R, R, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.

US Patent:

20090215803, Aug 27, 2009

Filed:

Oct 23, 2006

Appl. No.:

12/083749

Inventors:

Kenneth D. Rice - San Rafael CA, US
Neel Kumar Anand - Burlingame CA, US
Arlyn Arcalas - South San Francisco CA, US
Charles M. Blazey - San Francisco CA, US
Joerg Bussenius - Foster City CA, US
Wai Ki Vickey Chan - San Francisco CA, US
Hongwang Du - Millbrae CA, US
Sergey Epshteyn - Fremont CA, US
Mohamed Abdulkader Ibrahim - Mountain View CA, US
Patrick Kearney - San Francisco CA, US
Abigail R. Kennedy - Oakland CA, US
Moon Hwan Kim - Palo Alto CA, US
Jean-Claire Limun Manalo - Dale City CA, US
Csaba J. Peto - Alameda CA, US
Tsze H. Tsang - El Cerrito CA, US
Amy Lew Tsuhako - Milpitas CA, US
Peiwen Zhou - Palo Alto CA, US
Elena S. Koltun - Foster City CA, US

International Classification:

A61K 31/513
C07D 403/02
C12N 9/99
A61P 35/00

US Classification:

514274, 544316, 435184

Abstract:

A compound having Formula (I) or a pharmaceutically acceptable salt thereof, wherein X, Rand Rare defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.

US Patent:

20080249079, Oct 9, 2008

Filed:

Dec 28, 2005

Appl. No.:

11/722719

Inventors:

Jeff Chen - San Francisco CA, US
Lisa Esther Dalrymple Meyr - San Leandro CA, US
Sergey Epshteyn - Fremont CA, US
Timothy Patrick Forsyth - Hayward CA, US
Tai Phat Huynh - Oakland CA, US
Mohamed Abdulkader Ibrahim - Mountain View CA, US
James W. Leahy - San Leandro CA, US
Gary Lee Lewis - San Francisco CA, US
Grace Mann - Brisbane CA, US
Larry W. Mann - Richland MI, US
Robin Tammie Noguchi - San Bruno CA, US
Brian Hugh Ridgway - Belmont CA, US
Joan Cruz Sangalang - San Francisco CA, US
Kevin Luke Schnepp - Elk Grove CA, US
Xian Shi - San Bruno CA, US
Craig Stacy Takeuchi - Burlingame CA, US
Matthew Alan Williams - San Mateo CA, US
John Nuss - Danville CA, US
Atwood K. Cheung - Cambridge MA, US

Assignee:

EXELIXIS, INC. - South San Francisco CA

International Classification:

A61K 31/506
C07D 413/14
A61K 31/5377
A61K 31/519
A61P 35/00
C07D 403/14
C07D 403/12

US Classification:

51421018, 544324, 544122, 514275, 5142365, 514326, 544295, 5142651, 5142102

Abstract:

p-00010000

US Patent:

20070275952, Nov 29, 2007

Filed:

Mar 19, 2004

Appl. No.:

10/549300

Inventors:

Lynne Bannen - Pacifica CA, US
S. Brown - San Carlos CA, US
Wei Cheng - South San Francisco CA, US
Vasu Jammalamadaka - Pleasanton CA, US
John Nuss - Danville CA, US
Morrison Mac - San Francisco CA, US
Jason Parks - Sacramento CA, US
Matthew Williams - San Mateo CA, US
Wei Xu - Danville CA, US
Atwood Cheung - Cambridge MA, US
Lisa Dalrymple - San Francisco CA, US
Sergey Epshteyn - Fremont CA, US
Mohamed Ibrahim - Mountain View CA, US
James Leahy - San Leandro CA, US
Gary Lewis - San Francisco CA, US
Robin Noguchi - San Bruno CA, US
Larry Mann - Michigan MI, US
Brian Ridway - Belmont CA, US
Joan Sangalang - Mountain View CA, US
Kevin Schnepp - Elk Grove CA, US
Xian Shi - San Bruno CA, US
Richard Khoury - Redwood City CA, US

Assignee:

Exelixis, Inc. - South San Francisco CA

International Classification:

A61K 31/41
A61K 31/44
A61K 31/445
A61K 31/497
A61K 31/535
A61K 31/551
A61P 35/00
C07D 243/08
C07D 285/10
C07D 401/14
C07D 413/00
C07D 417/02
C12N 5/00
C12Q 1/00

US Classification:

514218000, 435375000, 435004000, 514235800, 514252110, 514252140, 514253060, 514253100, 514254030, 514318000, 514342000, 514362000, 540575000, 544121000, 544295000, 544357000, 544363000, 544364000, 544367000, 546194000, 546268700, 548135000

Abstract:

The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.

US Patent:

20070208166, Sep 6, 2007

Filed:

Oct 22, 2004

Appl. No.:

10/576932

Inventors:

Deborah Baly - Lafayette CA, US
Adam Galan - Alameda CA, US
Mohamed Ibrahim - Mountain View CA, US
Christopher Jaeger - Brisbane CA, US
Patrick Kearney - San Francisco CA, US
James Leahy - San Leandro CA, US
Gary Lewis - San Francisco CA, US
Kirk McMillan - Burlingame CA, US
Robin Noguchi - San Bruno CA, US
John Nuss - Danville CA, US
Jason Parks - Sacramento CA, US
Kevin Schnepp - Elk Grove CA, US
Xian Shi - San Bruno CA, US
Matthew Williams - San Mateo CA, US
Wei Xu - Danville CA, US
Wentao Zhang - Foster City CA, US

Assignee:

Exelixis, Inc. - South San Franciso CA

International Classification:

C07D 471/02

US Classification:

534766000, 564152000, 546336000, 548492000, 546118000, 546272400, 548495000, 548537000, 544250000, 544333000, 544284000, 548161000, 544278000, 544360000, 540496000, 546167000, 564050000, 546146000, 548470000, 549362000, 544386000, 548215000, 548364100, 546229000, 548190000, 546114000

Abstract:

The invention provides compounds and methods for inhibition of kinases, such as those of the TAO family, more specifically KIAA1361, TAO, and JIK kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

US Patent:

20070161651, Jul 12, 2007

Filed:

Apr 8, 2004

Appl. No.:

10/552426

Inventors:

Mohamed Ibrahim - Mountain View CA, US
James Leahy - , US
Joan Sangalang - , US
Kevin Schnepp - , US
Xian Shi - , US
John Nuss - , US

Assignee:

EXELIXIS, INC. - San Francisco CA

International Classification:

A61K 31/517
A61K 31/506
C07D 403/04

US Classification:

514256000, 514266210, 544330000, 544284000

Abstract:

The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.

US Patent:

20060211709, Sep 21, 2006

Filed:

May 2, 2003

Appl. No.:

10/513081

Inventors:

Chris Buhr - Redwood City CA, US
Sunghoon Ma - Foster City CA, US
Zerom Tesfai - San Leandro CA, US
Longcheng Wang - South San Francisco CA, US
Erick Co - Redwood City CA, US
Sergey Epshteyn - Fremont CA, US
Abigail Kennedy - San Leandro CA, US
Baili Chen - Palo Alto CA, US
Larisa Dubenko - San Francisco CA, US
Neel Anand - Burlingame CA, US
Tsze Tsang - El Cerrito CA, US
John Nuss - Danville CA, US
Kenneth Rice - Mill Valley CA, US
Mohamed Ibrahim - Mountain View CA, US
Xian Shi - San Bruno CA, US
James Leahy - San Leandro CA, US
Jeff Chen - San Francisco CA, US
Lisa Dalrymple - San Francisco CA, US
Timothy Forsyth - Hayward CA, US
Tai Huynh - Oakland CA, US
Grace Mann - Brisbane CA, US
Larry Mann - Redwood City CA, US
Craig Takeuchi - Burlingame CA, US

International Classification:

A61K 31/497
C07D 403/02

US Classification:

514255050, 544405000

Abstract:

Substituted aryl 1,4-pyrazine derivatives and their use in treating anxiety disorders, depression and stress related disorders are disclosed.