Paul S Kenny

US Patent:

8354447, Jan 15, 2013

Filed:

Sep 10, 2003

Appl. No.:

10/527525

Inventors:

Athina Markou - Del Mar CA, US
Paul Kenny - San Diego CA, US
Neil Paterson - Encinitas CA, US
Svetlana Semenova - Carlsbad CA, US

Assignee:

The Scripps Research Institute - La Jolla CA

International Classification:

A01N 43/16
A01N 43/40
A61K 31/35
A61K 31/435

US Classification:

514454, 514277

Abstract:

Methods are provided for treating disorders associated with mGlu receptors by simultaneously inhibiting at least two mGluRs belonging to at least two different groups. In one embodiment, there are provided methods for treating a disorder associated with mGlu receptors 2, 3, and 5, including administering to a subject in need thereof an effective amount of at least one antagonist which modulates mGluR2, mGluR3, and mGluRS. The disorders treated by the method include, for example, nicotine addiction, cocaine addiction, and depression.

US Patent:

20130210849, Aug 15, 2013

Filed:

Dec 19, 2012

Appl. No.:

13/694637

Inventors:

Athina Markou - Del Mar CA, US
Paul Kenny - Jupiter FL, US
Neil Paterson - Los Angeles CA, US
Svetlana Semenova - San Diego CA, US

International Classification:

A61K 31/44
A61K 31/352

US Classification:

514277

Abstract:

Methods are provided for treating disorders associated with mGlu receptors by simultaneously inhibiting at least two mGluRs belonging to at least two different groups. In one embodiment, there are provided methods for treating a disorder associated with mGlu receptors 2, 3, and 5, including administering to a subject in need thereof an effective amount of at least one antagonist which modulates mGluR2, mGluR3, and mGluR5. The disorders treated by the method include, for example, nicotine addiction, cocaine addiction, and depression.