Paul L Nelson

US Patent:

7193041, Mar 20, 2007

Filed:

Apr 19, 2001

Appl. No.:

09/839696

Inventors:

Brian Perry - Fremont CA, US
Paul S. Nelson - Union City CA, US
Thomas H. Smith - San Carlos CA, US

Assignee:

Clontech Laboratories, Inc. - Mountain View CA

International Classification:

C07D 305/00

US Classification:

530344, 530412, 530413, 549263, 549299, 549300, 549200

Abstract:

Purification of poly-amino acid-tagged recombinant proteins has been improved by the use of a carboxymethylated aspartate ligand complexed with a third-block transition metal having an oxidation state of 2 and a coordination number of 6. A method for synthesizing the metal ion-CM-Asp complex is also described. Further, the metal ion-CM-Asp complex can be used for screening protein function.

US Patent:

20050079855, Apr 14, 2005

Filed:

Aug 16, 2004

Appl. No.:

10/919820

Inventors:

Rashesh Jethi - Fremont CA, US
Paul Nelson - San Francisco CA, US
Venkatesan Raghavan - San Francisco CA, US

International Classification:

H04M011/00

US Classification:

455403000, 455414100

Abstract:

An architecture is presented that enables a Mobile Virtual Network Operator (MVNO) to create a branded wireless offering. An MVNO-enabler (MVNE) system acts as an intermediary between a brand system and a wireless network. The MVNE system controls customer management, order management, applications management, and billing management. In one embodiment, the MVNE system comprises modules for customer management, order management, applications management, and billing management. In another embodiment, the MVNE system comprises interfaces to third party systems that provide these services. In yet another embodiment, the MVNE system can comprise interfaces to a plurality of brand systems, a plurality of wireless networks, and a plurality of third party systems. By using various interfaces, a customized wireless offering can be created.

US Patent:

20050080875, Apr 14, 2005

Filed:

Aug 20, 2004

Appl. No.:

10/923442

Inventors:

Rashesh Jethi - Fremont CA, US
Paul Nelson - San Francisco CA, US
Venkatesan Raghavan - San Francisco CA, US

International Classification:

G06F015/16

US Classification:

709217000, 370328000

Abstract:

An architecture is presented that enables a Mobile Virtual Network Operator (MVNO) to create a branded wireless offering. An MVNO-enabler (MVNE) system acts as an intermediary between a brand system and a wireless network. The MVNE system controls customer management, order management, applications management, and billing management. In one embodiment, the MVNE system comprises modules for customer management, order management, applications management, and billing management. In another embodiment, the MVNE system comprises interfaces to third party systems that provide these services. In yet another embodiment, the MVNE system can comprise interfaces to a plurality of brand systems, a plurality of wireless networks, and a plurality of third party systems. By using various interfaces, a customized wireless offering can be created.

US Patent:

20060122378, Jun 8, 2006

Filed:

Jan 19, 2006

Appl. No.:

11/336748

Inventors:

Brian Perry - Fremont CA, US
Paul Nelson - Union City CA, US
Thomas Smith - San Carles CA, US

International Classification:

C07K 1/10

US Classification:

530414000

Abstract:

Purification of poly-amino acid-tagged recombinant proteins has been improved by the use of a carboxymethylated aspartate ligand complexed with a third-block transition metal having an oxidation state of 2 and a coordination number of 6. A method for synthesizing the metal ion-CM-Asp complex is also described. Further, the metal ion-CM-Asp complex can be used for screening protein function.

US Patent:

54514630, Sep 19, 1995

Filed:

Jun 3, 1993

Appl. No.:

8/071937

Inventors:

Paul S. Nelson - Union City CA
Mark A. Kent - Sunnyvale CA

Assignee:

Clontech Laboratories, Inc. - Palo Alto CA

International Classification:

C07C22900
C07D21900
C07D31188
C07F 922

US Classification:

428402

Abstract:

A trifunctional reagent possessing a primary hydroxyl, a secondary hydroxyl, and a primary amino group. This reagent is useful in solid phase oligonucleotide synthesis for the convenient labeling of the 3'-terminus. The secondary hydroxyl may be an phosphoramidite derivative permitting the attachment to the solid phase support. The reporter molecule may be attached to the trifunctional molecule prior to the completion of the oligonucleotide synthesis or after the oligonucleotide is cleaved from the support. A preferred species of this trifunctional molecule is shown below.

US Patent:

51418134, Aug 25, 1992

Filed:

Aug 28, 1989

Appl. No.:

7/399658

Inventors:

Paul S. Nelson - Union City CA

Assignee:

Clontech Laboratories, Inc. - Palo Alto CA

International Classification:

C07H 100
C07H 2104
C03C 1200
C07C21102

US Classification:

428402

Abstract:

The subject invention concerns a novel multifunctional solid support reagent which is useful in solid phase oligonucleotide synthesis. Specifically, the reagent is used in a solid phase oligonucleotide process to chemically modify the 3' terminus of a synthetic oligonucleotide with any chemical functional group. The invention reagent can be used to construct 3' labeled oligonucleotide hybridization probes to detect the presence of a target polynucleotide in biological and clinical samples.

US Patent:

54018374, Mar 28, 1995

Filed:

Aug 24, 1992

Appl. No.:

7/934582

Inventors:

Paul S. Nelson - Union City CA

Assignee:

Clontech Laboratories, Inc. - Palo Alto CA

International Classification:

C07H 100
C07H 2104
C03C 1200
C07C21102

US Classification:

536 2532

Abstract:

A method for derivatizing and labeling the 3'-terminus of an oligonucleotide during solid phase synthesis comprising the use of a multifunctional reagent whose preferred structure is shown below. ##STR1## wherein CPG is controlled pore glass beads, Fmoc is 9-fluorenylmethyoxycarbonyl, and the alkylamine contains 1 to 50 carbon atoms.

US Patent:

59626410, Oct 5, 1999

Filed:

Aug 16, 1996

Appl. No.:

8/698747

Inventors:

Paul S. Nelson - Union City CA
Steven R. Kain - Belmont CA

Assignee:

CLONTECH Laboratories, Inc. - Palo Alto CA

International Classification:

C07K 122

US Classification:

530344

Abstract:

Purification of poly-amino acid-tagged recombinant proteins has been improved by the use of a carboxymethylated aspartate ligand complexed with a third-block transition metal having an oxidation state of 2. sup. + and a coordination number of 6. A method for synthesizing the metal ion-CM-Asp complex is also described. Further, the metal ion-CM-Asp complex can be used for screening protein function.