Paul C Weiss

US Patent:

20130244037, Sep 19, 2013

Filed:

Mar 13, 2013

Appl. No.:

13/801349

Inventors:

Paul S. Weiss - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

B01J 8/16

US Classification:

4284022, 264 4

Abstract:

Methods and assemblies for the construction of liquid-phase alloy nanoparticles are presented. Particle formation is directed by molecular self-assembly and assisted by sonication. In some embodiments, eutectic gallium-indium (EGaIn) nanoparticles are formed. In these embodiments, the bulk liquid alloy is ultrasonically dispersed, fast thiolate self-assembly at the EGaIn interface protects the material against oxidation. The assembly shell has been designed to include intermolecular hydrogen bonds, which induce surface strain, assisting in cleavage of the alloy particles to the nanoscale. X-ray diffraction and TEM analyses reveal that the nanoscale particles are in an amorphous or liquid phase, with no observed faceting.

US Patent:

20210346889, Nov 11, 2021

Filed:

Aug 21, 2019

Appl. No.:

17/269985

Inventors:

- Oakland CA, US
- Singapore, SG
Joshua A. A. Jackman - Bradenton FL, US
Nam-Joon Cho - Singapore, SG
Paul S. Weiss - Los Angeles CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
NANYANG TECHNOLOGICAL UNIVERSITY - Singapore

International Classification:

B01L 3/00
C12N 15/90

Abstract:

A microfluidic device is disclosed that is used to process cells for the intracellular delivery of molecules or other cargo. The device includes one or more microchannels disposed in a substrate or chip and is fluidically coupled to an inlet configured to receive a solution containing the cells and the molecules or other cargo to be delivered intracellularly to the cells. Each of the one or more microchannels has one or more constriction regions formed therein, wherein the inner surface(s) of the microchannels and the one or more constriction regions have a lipid bilayer disposed thereon. In some embodiments, multiple microfluidic devices operating in parallel are used to process large numbers of cells. The device and method have particularly applicability to delivering gene-editing molecules intracellularly to cells.

US Patent:

20210308671, Oct 7, 2021

Filed:

Aug 16, 2019

Appl. No.:

17/268955

Inventors:

- Oakland CA, US
Gail Vinnacombe - Los Angeles CA, US
Liv Heidenreich - Los Angeles CA, US
Naihao Chiang - Los Angeles CA, US
Yao Gong - Los Angeles CA, US
Paul S. Weiss - Los Angeles CA, US
Steven J. Jonas - Los Angeles CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

B01L 3/00
G01N 33/543
G01N 21/65
G01N 21/64
G01N 33/574
C01G 7/00
G02B 21/00
G02B 21/16

Abstract:

Systems and methods are disclosed that utilize metal nanostructures that are synthesized in situ along the internal surfaces of a microfluidic device. The nanostructures are formed by initial deposition of metallic seeds followed by flowing growth and reducing agent solutions into the capillaries/microfluidic channels to grow the nanostars. The nanostructures may optionally be functionalized with a capture ligand. The capture ligand may be used to selectively bind to certain cells (e.g., circulating tumor cells). The cells may be removed by a beam of light (e.g., laser beam) that induces localized heating at the surface location(s) containing the nanostructures. The plasmonic nature of the nanostructures can be used to heat the nanostructure(s) locally for the selective removal of one or certain cells. The nanostructures may be used to acquire Raman spectra of molecules or other small objects that are bound thereto for identification and quantification.

US Patent:

20210223240, Jul 22, 2021

Filed:

Feb 12, 2021

Appl. No.:

17/175190

Inventors:

- New York NY, US
- Oakland CA, US
Kyungae YANG - New York NY, US
Paul S. WEISS - Los Angeles CA, US
Nako NAKATSUKA - Adliswill, CH

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

G01N 33/543
G01N 27/414
G01N 33/68
C12Q 1/6825
C12Q 1/6869

Abstract:

Devices for detecting at least one target molecule in a sample are provided. The devices comprise a field-effect transistor and an aptamer attached to the field-effect transistor. The aptamer comprises a capture region and a stem region, wherein the target molecule can selectively bind to the capture region of the aptamer. The stem region can change a conformation of the aptamer when the capture region binds to the target molecule. Techniques for detecting a target molecule using such devices are also provided.

US Patent:

20200397948, Dec 24, 2020

Filed:

Mar 11, 2019

Appl. No.:

16/979215

Inventors:

- Oakland CA, US
Tara L. AGHALOO - Sherman Oaks CA, US
Paul S. WEISS - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61L 27/38
A61L 27/52
A61L 27/26

Abstract:

A dental hydrogel composition comprising: (a) polysaccharide; (b) polydopamine conjugated to the polysaccharide, wherein between 5 and 35 percent of polysaccharide sugar moieties are conjugated to polydopamine; (c) RGD peptide coupled to the polysaccharide-poly-dopamine conjugate; and (d) moieties that are crosslinkable upon exposure to light coupled to the polysaccharide; wherein components (a)-(d) are disposed in the composition such that the hydrogel composition: exhibits an adhesive strength of at least 10 kPa upon cross linking of crosslinkable moieties; and exhibits an elasticity between 5 kPa and 100 kPa upon cross linking of crosslinkable moieties.

US Patent:

20200098577, Mar 26, 2020

Filed:

Sep 25, 2019

Appl. No.:

16/583101

Inventors:

- Oakland CA, US
Qing Yang - Los Angeles CA, US
Natcha Wattanatorn - Los Angeles CA, US
Chuanzhen Zhao - Los Angeles CA, US
Logan A. Stewart - Los Angeles CA, US
Steven J. Jonas - Hawthorne CA, US
Paul S. Weiss - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

H01L 21/308
H01L 21/3065

Abstract:

A robust and general fabrication/manufacturing method is described herein for the fabrication of periodic three-dimensional (3D) hierarchical nanostructures in a highly scalable and tunable manner. This nanofabrication technique exploits the selected and repeated etching of spherical particles that serve as resist material and that can be shaped in parallel for each processing step. The method enables the fabrication of periodic, vertically aligned nanotubes at the wafer scale with nanometer-scale control in three dimensions including outer/inner diameters, heights/hole-depths, and pitches. The method was utilized to construct 3D periodic hierarchical hybrid silicon and hybrid nanostructures such as multi-level solid/hollow nanotowers where the height and diameter of each level of each structure can be configured precisely as well as 3D concentric plasmonic supported metal nanodisk/nanorings with tunable optical properties on a variety of substrates.

US Patent:

20190276787, Sep 12, 2019

Filed:

Jan 31, 2019

Appl. No.:

16/264140

Inventors:

- Oakland CA, US
Paul S. Weiss - Los Angeles CA, US
Tara L. Aghaloo - Sherman Oaks CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12M 1/12
A61K 35/28
A61L 27/54

Abstract:

The present invention relates to biomimetic membrane compositions and methods for making and using them.

US Patent:

20150328616, Nov 19, 2015

Filed:

May 13, 2015

Appl. No.:

14/711738

Inventors:

- PASADENA CA, US
William A. GODDARD, III - PASADENA, CA
Paul S WEISS - LOS ANGELES CA, US
John RANDALL - RICHARDSON TX, US

International Classification:

B01J 19/00

Abstract:

Surface mediated polymer synthesizing methods and related systems and materials are described where monomers are attached to monomer binding regions on a surface and subsequently form chemical bonds with adjacent monomers on the surface to form linear polymers selected from polynucleotide, polypeptides and polysaccharides.

Address:

10406 Sundance Ct, Charlotte, NC 28277

VIN:

JNKBV61E07M721279

Make:

INFINITI

Model:

G35

Year:

2007