Rakesh D Patel

US Patent:

20130324846, Dec 5, 2013

Filed:

Feb 17, 2012

Appl. No.:

14/000106

Inventors:

Anna N. Yaroslavsky - North Andover MA, US
Rakesh Patel - Sharon MA, US
Dennis Wirth - Wilmington MA, US

Assignee:

UNIVERSITY OF MASSACHUSETTS - Boston MA

International Classification:

A61B 5/00
A61M 31/00
A61M 5/00

US Classification:

600431

Abstract:

Currently most cancers, including breast cancers, are removed without any intraoperative margin control. Post-operative methods inspect 1-2% of the surgical margin and are prone to sampling errors. The present invention relates to an optical imaging system that will enable evaluation of the surgical margin in vivo and in real-time. The invention provides for simultaneous fluorescence and fluorescence polarization imaging. The contrast of the acquired images will be enhanced using fluorescent agents approved for diagnostic use in patients. As the staining pattern of fluorescence images is similar to that of histology, and the values of fluorescence polarization are significantly higher in cancerous as compared to normal cells, the invention provides for further improvements in diagnostic methods. The systems and methods can be applied to the intra-operative delineation of cancerous tissue.

US Patent:

20180206727, Jul 26, 2018

Filed:

Dec 11, 2017

Appl. No.:

15/838163

Inventors:

Anna N. Yaroslavsky - North Andover MA, US
Rakesh Patel - Sharon MA, US
Dennis Wirth - Wilmington MA, US

Assignee:

The University of Massachusetts - Boston MA

International Classification:

A61B 5/00
G06T 7/90
A61M 31/00
A61M 5/00
G06T 7/00

Abstract:

Currently most cancers, including breast cancers, are removed without any intraoperative margin control. Post-operative methods inspect 1-2% of the surgical margin and are prone to sampling errors. The present invention relates to an optical imaging system that will enable evaluation of the surgical margin in vivo and in real-time. The invention provides for simultaneous fluorescence and fluorescence polarization imaging. The contrast of the acquired images will be enhanced using fluorescent agents approved for diagnostic use in patients. As the staining pattern of fluorescence images is similar to that of histology, and the values of fluorescence polarization are significantly higher in cancerous as compared to normal cells, the invention provides for further improvements in diagnostic methods. The systems and methods can be applied to the intra-operative delineation of cancerous tissue.

US Patent:

20150164327, Jun 18, 2015

Filed:

Jul 15, 2013

Appl. No.:

14/414675

Inventors:

- Boston MA, US
Robert H. Giles - Lowell MA, US
Cecil S. Joseph - Lowell MA, US
Rakesh Patel - Sharon MA, US

Assignee:

UNIVERSITY OF MASSACHUSETTS - Boston MA

International Classification:

A61B 5/00
A61B 5/05

Abstract:

The present invention relates to the use of optical and terahertz imaging of tissue for measuring characteristics to assist in diagnosis. A light delivery and collection system is used that can aid in the detection of tumor margins, for example. A data processor processes the image data to determine characteristics of a region of tissue.