Randall Lee Murphy

US Patent:

8431698, Apr 30, 2013

Filed:

Aug 29, 2008

Appl. No.:

12/201680

Inventors:

Philip T. Neff - Golden CO, US
Randall B. Murphy - Glenmoore PA, US
Bruce Bryan - Beverly Hills CA, US

Assignee:

BioLume Inc. - Morrisville NC

International Classification:

C07D 491/00
C07D 495/00
C07D 497/00

US Classification:

544350, 424 96, 435 8

Abstract:

Bioluminescent endoscopy methods and compounds, wherein an anatomical object is examined by means of filling, perfusing, intubating, injecting, or otherwise administering a solution containing a bioluminescent substance or a mixture of luciferin and luciferase which produces bioluminescence, wherein a color or monochrome image of the object is constituted using the images and information based on bioluminescent emitted by the bioluminescent substance. Procedures are demonstrated which allow bioluminescent solutions to be perfused into certain tissue regions, such as but not limited to the common biliary duct, genitourinary tract, gastro-intestinal tract, cardiovascular system and lymphatic system wherein said structures may be conveniently visualized during surgery to avoid damage to these structures. Such images may also be combined with visual light images. Methods of detection of cancer cells using bioluminescence are provided.

US Patent:

20130058872, Mar 7, 2013

Filed:

Sep 11, 2012

Appl. No.:

13/610242

Inventors:

Philip T. Neff - Golden CO, US
Bruce Bryan - Beverly Hills CA, US
Randall B. Murphy - Glenmoore PA, US

International Classification:

A61K 49/00

US Classification:

424 96

Abstract:

Bioluminescent endoscopy methods in which bioluminescent generating system components are combined ex vivo immediately prior to injection or infusion into a tissue area of interest to enable bioluminescent viewing of the tissue. The bioluminescent generating system components are combined by simultaneous injection into a Y tube or other in-line mixing chamber receiving fluid inputs from two or more fluid conduits and providing a fluid output to at least one fluid conduit. The mixed components which are the output of such multi lumen mixing system is injected into a hollow viscus organ or otherwise applied to organs and/or tissues of the body.