Richard Martin Cross

US Patent:

8598354, Dec 3, 2013

Filed:

Jun 3, 2011

Appl. No.:

13/153350

Inventors:

Michael K. Riscoe - Tualatin OR, US
Jane X. Kelly - Lake Oswego OR, US
Rolf W. Winter - Portland OR, US
David J. Hinrichs - Lake Oswego OR, US
Martin J. Smilkstein - Portland OR, US
Aaron Nilsen - Portland OR, US
Jeremy Burrows - Eysins, CH
Dennis Kyle - Lithia FL, US
Roman Manetsch - Tampa FL, US
Richard M. Cross - Brandon FL, US
Andrii Monastyrskyi - Tampa FL, US
David L. Flanigan - Riverview FL, US

Assignee:

University of South Florida - Tampa FL
Medicines for Malaria Venture - Geneva

International Classification:

C07D 215/233
A61K 31/47
A61P 31/00
A61P 33/00
A61P 33/02
A61P 33/06

US Classification:

546153, 514312

Abstract:

Compounds of formula I:.

US Patent:

20130123258, May 16, 2013

Filed:

Oct 26, 2012

Appl. No.:

13/661300

Inventors:

Roman Manetsch - Tampa FL, US
Richard Matthew Cross - Brandon FL, US
Dennis Edward Kyle - Lithia FL, US
Tina Susanna Mutka - Tampa FL, US
Alexis Nichole LaCrue - Temple Terrace FL, US
Jordany Richarlson Maignan - Tampa FL, US
Fabian Ernesto Saenz - Quito, EC

International Classification:

C07D 215/233
C07D 413/04
C07D 401/04
C07D 215/56

US Classification:

5142352, 514312, 546156, 546153, 544128, 544363, 51425307

Abstract:

Provided are 4(1H)-quinolone derivatives effective in inhibiting or eliminating the viability of at least one of the stages in the life-cycle of the malarial parasite, and to show a reduced propensity to induce resistance to the compound by the target parasite. In particular, the compounds can be derivatives of phenoxyethoxy-quinolones, and including, but not only, 7-(2-phenoxyethoxy)quinolin derivatives. These compounds may be administered by themselves, with at least one other derivative compound, or with other antimalarial compounds, to an animal or human subject. The therapeutic compositions can be and formulated to reduce the extent of a infection in the recipient subject, or to reduce the likelihood of the onset or establishment of a infection if administered prior to the parasite contacting the subject. The therapeutic compositions can be formulated to provide an effective single dose amount of an antimalarial compound or multiple doses for administering over a period of time.

US Patent:

20140045888, Feb 13, 2014

Filed:

Oct 16, 2013

Appl. No.:

14/055757

Inventors:

- Geneva, CH
Martin J. Smilkstein - Portland OR, US
Aaron Nilsen - Portland OR, US
Jeremy Burrows - Eysins, CH
Dennis Kyle - Lithia FL, US
Roman Manetsch - Tampa FL, US
Richard M. Cross - Brandon FL, US
Andrii Monastyrskyi - Tampa FL, US
David L. Flanigan - Riverview FL, US

Assignee:

Oregon Health & Science University - Portland OR
Medicines for Malaria Venture - Geneva 15
University of South Florida - Tampa FL
The Government of the United States of America dba The Department of Veterans Affairs - Washington DC

International Classification:

C07D 215/233

US Classification:

514312

Abstract:

Compounds of formula I:or formula II: