Robert E Bryant

US Patent:

7749730, Jul 6, 2010

Filed:

Nov 3, 2006

Appl. No.:

11/592180

Inventors:

Robert W. Bryant - Princeton NJ, US
S. Paul Lee - Newtown PA, US
R. Kyle Palmer - Cranbury NJ, US
Qifeng Yang - Belle Meade NJ, US
M. N. Tulu Buber - Newtown PA, US

Assignee:

Redpoint Bio Corporation - Ewing NJ

International Classification:

C12P 1/00

US Classification:

435 41

Abstract:

There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods suffer from a lack of sensitivity, low throughput, and are labor intensive. The claimed methods provide fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5.

US Patent:

7875452, Jan 25, 2011

Filed:

Sep 30, 2008

Appl. No.:

12/285140

Inventors:

Robert W. Bryant - Princeton NJ, US
S. Paul Lee - Yardley PA, US
Rok Cerne - Lawrenceville NJ, US
M. N. Tulu Buber - Newtown PA, US
Ivona Bakaj - Cranbury NJ, US
Roy Kyle Palmer - Cranbury NJ, US

Assignee:

Redpoint Bio Corporation - Ewing NJ

International Classification:

C12N 5/10
C12N 15/12
C12N 15/63
C12N 1/21

US Classification:

435325, 435 691, 4352523, 4353201, 536 235

Abstract:

There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods, especially electrophysiological, suffer from a lack of sensitivity, rapid signal loss, low throughput, and are labor intensive. The claimed methods and compositions provide electrophysiology methods that allow prolonged sample testing and fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5.

US Patent:

20070207093, Sep 6, 2007

Filed:

Nov 3, 2006

Appl. No.:

11/592228

Inventors:

Robert Bryant - Princeton NJ, US
Roy Palmer - Cranbury NJ, US
Rok Cerne - Plainsboro NJ, US
Karnail Atwal - Pennington NJ, US
Seunghun Lee - Newtown PA, US
Anita Atwal - Pennington NJ, US

International Classification:

A61K 8/49
A61K 8/40

US Classification:

424049000, 514313000, 514408000, 514357000, 514419000, 514367000, 514394000, 514418000, 514639000, 514237500

Abstract:

The present invention is directed to the use of a compound having the formula wherein R, R, R, R, L, and Lare defined herein. The compounds of the present invention are useful as inhibitors of certain taste perceptions and functions. The invention is also directed to compositions comprising a compound according to the above formula.

US Patent:

20080070865, Mar 20, 2008

Filed:

Sep 17, 2007

Appl. No.:

11/856518

Inventors:

R. KYLE PALMER - Cranbury NJ, US
Robert W. Bryant - Princeton NJ, US
Dennis Sprous - Ware MA, US

Assignee:

Redpoint Bio Corporation - Ewing NJ

International Classification:

A61K 31/662
A61P 39/00
C07K 14/465
C07K 14/47
C07K 14/705
C12N 5/06
C12N 5/08

US Classification:

514 75, 435375, 530350

Abstract:

The present invention is directed to the use of a compound having the formulawherein R, R, R, m, n and p are defined herein. The compounds of the present invention are useful as inhibitors of certain taste perceptions and functions. The invention is also directed to compositions comprising a compound according to the above formula.

US Patent:

20080153845, Jun 26, 2008

Filed:

Oct 29, 2007

Appl. No.:

11/926911

Inventors:

R. Kyle PALMER - Cranbury NJ, US
Daniel Long - Philadelphia PA, US
Heather Devantier - Philadelphia PA, US
S. Paul Lee - Newtown PA, US
Robert Bryant - Princeton NJ, US

Assignee:

REDPOINT BIO CORPORATION - Ewing NJ

International Classification:

A61K 31/497
A61P 27/00

US Classification:

51425311

Abstract:

The present invention is directed to the use of TRPV1 antagonists as inhibitors of certain taste perceptions and functions. The invention is also directed to, among other things, compositions comprising the TRPV1 antagonists that can be used in pharmaceutical, food, and other products to inhibit certain taste functions and perceptions.

US Patent:

20100248987, Sep 30, 2010

Filed:

Feb 4, 2010

Appl. No.:

12/700263

Inventors:

Seunghun Paul Lee - Newton PA, US
Qifeng Yang - Belle Mead NJ, US
Robert W. Bryant - Princeton NJ, US
Tulu Buber - Newton PA, US

Assignee:

Redpoint Bio Corporation - Ewing NJ

International Classification:

C12Q 1/02
C40B 30/06

US Classification:

506 10, 435 29

Abstract:

The invention relates an assay useful for screening and identifying compounds as modulators of lower alkyl phenol activation of TRPA1. Thymol, a lower alkyl phenol anti-infective and the active ingredient in, e.g., mouthwashes, is stringent and has an objectionable burning taste sensation. Thymol activates the transient receptor potential like ion channel TRPA1. The assay described and claimed herein involves measurement of activation of TRPA1 and enables the screening of compounds that inhibit lower alkyl phenol, or thymol activation of TRPA1. Inhibitors of thymol activation of TRPA1 can be used to prevent the objectionable taste of thymol in medical uses where taste limits acceptance.

US Patent:

20100248988, Sep 30, 2010

Filed:

May 28, 2010

Appl. No.:

12/790013

Inventors:

Robert W. BRYANT - Princeton NJ, US
S. Paul Lee - Yardley PA, US
R. Kyle Palmer - Cranbury NJ, US
Qifeng Yang - Ewing NJ, US

Assignee:

Redpoint Bio Corporation - Ewing NJ

International Classification:

C40B 30/06
C07H 21/04

US Classification:

506 10, 536 231

Abstract:

There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods suffer from a lack of sensitivity, low throughput, and are labor intensive. The claimed methods provide fluorescent assays with an optical readout that gives rapid readout of the results, has a high signal to noise background ratio, are easy to use, can be modified for automation and miniaturization, and provide verification that a compound specifically modulates TRPM5.

US Patent:

20130131909, May 23, 2013

Filed:

Jan 11, 2013

Appl. No.:

13/739132

Inventors:

GENERAL ELECTRIC COMPANY - Schenectady NY, US
Robert Francis BRYANT - Melbourne FL, US
Mitchell Scott WILLS - Melbourne FL, US
James KNOX - Melbourne FL, US

Assignee:

GENERAL ELECTRIC COMPANY - Schenectady NY

International Classification:

B61L 27/00

US Classification:

701 23, 701117, 701 70

Abstract:

A method includes, responsive to a determination that a first vehicle system to be received in a vehicle yard is longer than a length of a receiving route of the vehicle yard that is designated for receiving the first vehicle system, processing a first movement plan to generate a revised movement plan. The first movement plan governs movement of the first vehicle system and one or more second vehicle systems in a transportation network that includes the vehicle yard. The revised movement plan is generated based at least in part on a designated time restriction for the first vehicle system to travel to and be received within the vehicle yard on the receiving route. The method also includes controlling at least one of the first vehicle system or at least one of the one or more second vehicle systems based on the revised movement plan.