Robert G Matteson

US Patent:

20140188213, Jul 3, 2014

Filed:

Feb 13, 2014

Appl. No.:

14/179835

Inventors:

- Baltimore MD, US
Hala J. Tomey - Washington DC, US
Jon R. Rosar - Stevenson MD, US
Robert C. Matteson - Ellicott City MD, US
George L/ Coles - Baltimore MD, US
Jason J. Benkoski - Ellicott City MD, US
Morgana M. Trexler - Baltimore MD, US

Assignee:

Johns Hopkins University - Baltimore MD

International Classification:

A61F 2/82

US Classification:

623 142, 53455

Abstract:

Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.