Robert J Scarborough

US Patent:

7049297, May 23, 2006

Filed:

Mar 31, 2003

Appl. No.:

10/403218

Inventors:

Han-Cheng Zhang - Lansdale PA, US
Bruce E. Maryanoff - Forest Grove PA, US
Anjali Pandey - Fremont CA, US
Robert M. Scarborough - Half Moon Bay CA, US

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 38/00
A61K 31/416
C07K 5/00
C07D 277/04

US Classification:

514 19, 514 18, 514385, 514403, 530330, 530331, 548146, 548215, 548305, 5483335

Abstract:

The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indazole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.

US Patent:

7417030, Aug 26, 2008

Filed:

Mar 30, 2006

Appl. No.:

11/393529

Inventors:

Han-Cheng Zhang - Lansdale PA, US
Bruce E. Maryanoff - Forest Grove PA, US
Anjali Pandey - Fremont CA, US
Robert M. Scarborough - Half Moon Bay CA, US

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 38/00
A61K 31/416
C07K 5/00
C07D 277/04

US Classification:

514 19, 514 18, 514385, 514403, 530330, 530331, 548146, 548215, 548305, 5483335

Abstract:

The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indazole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.

US Patent:

20060166896, Jul 27, 2006

Filed:

Mar 30, 2006

Appl. No.:

11/393350

Inventors:

Han-Cheng Zhang - Lansdale PA, US
Bruce Maryanoff - Forest Grove PA, US
Anjali Pandey - Fremont CA, US
Robert Scarborough - Half Moon Bay CA, US

International Classification:

A61K 38/04

US Classification:

514019000

Abstract:

The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indazole peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.