Matthew Mack - Chicago IL, US Sandra Burke - Libertyville IL, US John Toner - Libertyville IL, US Keith Cromack - Gurnee IL, US
Assignee:
ABBOTT LABORATORIES - Abbott Park IL
International Classification:
A61F 2/06 A61K 31/4353 A61P 41/00 A61P 9/00
US Classification:
424423000, 514291000
Abstract:
A drug-eluting endoprosthesis is configured for inhibiting restenosis and thrombosis, and for promoting healing of a lesion in a body of a subject. Such an endoprosthesis includes at least a supporting structure and a therapeutically effective amount of the rapamycin analog is disposed thereon. The therapeutically effective amount of the rapamycin analog allows for the rapamycin analog to elute from the supporting structure so as to obtain a concentration of the rapamycin analog that is sufficient for inhibiting restenosis and/or inhibiting thrombosis. Also, the therapeutically effective amount of rapamycin analog is substantially devoid of inhibiting cell migration such that migrating cells promote healing of the lesion.
Compositions And Methods For Administering Dexamethasone Which Promote Human Coronary Artery Endothelial Cell Migration
Matthew Mack - Chicago IL, US Sandra Burke - Libertyville IL, US John Toner - Libertyville IL, US Keith Cromack - Gurnee IL, US
Assignee:
ABBOTT LABORATORIES - Abbott Park IL
International Classification:
A61F 2/06
US Classification:
623001420
Abstract:
A drug-eluting endoprosthesis is configured for inhibiting restenosis and thrombosis, and for promoting healing of a lesion in a body of a subject. Such an endoprosthesis includes at least a supporting structure and a therapeutically effective amount of dexamethasone is disposed thereon. The therapeutically effective amount of dexamethasone allows for the drug to elute from the supporting structure so as to obtain a concentration of dexamethasone that is sufficient for inhibiting restenosis and/or inhibiting thrombosis. Also, the therapeutically effective amount of dexamethasone is substantially devoid of inhibiting cell migration such that migrating cells promote healing of the lesion. Additionally, the therapeutically effective amount of dexamethasone induces cell migration such that migrating cells promote healing of the lesion.
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