Sean R Gallagher

US Patent:

6518024, Feb 11, 2003

Filed:

Dec 13, 1999

Appl. No.:

09/459685

Inventors:

Vi-En Choong - Chandler AZ
Song Shi - Phoenix AZ
George Maracas - Phoenix AZ
Sean Gallagher - Scottsdale AZ

Assignee:

Motorola, Inc. - Schaumburg IL

International Classification:

C12Q 168

US Classification:

435 6, 435 911, 435 912, 536 2433

Abstract:

This invention relates to apparatus and methods for detecting single base extension to an oligonucleotide array using electrochemical labels.

US Patent:

6572830, Jun 3, 2003

Filed:

Jun 21, 1999

Appl. No.:

09/337086

Inventors:

Jeremy W. Burdon - Scottsdale AZ
Rong-Fong Huang - Tempe AZ
David Wilcox - Albuquerque NM
Nicholas J. Naclerio - Barrington IL
Cynthia Ann Gorsuch Briscoe - Tempe AZ
Piotr Grodzinski - Chandler AZ
Huinan Yu - Chandler AZ
Robert Marrero - Chandler AZ
Sean Ross Gallagher - Scottsdale AZ
Barbara McNeil Foley - Phoenix AZ

Assignee:

Motorola, Inc. - Schaumburg IL

International Classification:

B01J 1000

US Classification:

42218629, 422129, 422186, 422240, 156 8911, 156 8912, 219678, 219687, 219756

Abstract:

A multilayered microfluidic device having a substantially monolithic structure is formed by sintering together a plurality of green-sheet layers. The substantially monolithic structure has an inlet port for receiving fluid, an outlet port for releasing fluid, and an interconnection between the inlet port and the outlet port. The substantially monolithic structure may also include a variety of components to enable useful interaction with the fluid, such as electrically conductive pathways, heaters, fluid sensors, fluid motion transducers, and optically transmissive portions. The components are preferably fabricated using thick-film or green-sheet technology and are preferably co-fired with and sintered to the green-sheet layers to become integral with the substantially monolithic structure.

US Patent:

6605454, Aug 12, 2003

Filed:

Mar 22, 2001

Appl. No.:

09/816512

Inventors:

Barbara Foley Barenburg - Gilbert AZ
Jeremy Burdon - Scottsdale AZ
Sean Gallagher - Scottsdale AZ
Piotr Grodzinski - Chandler AZ
Robert Marrero - Chandler AZ
Vijay Nair - Mesa AZ
David Rhine - Phoenix AZ
Thomas Smekal - Phoenix AZ

Assignee:

Motorola, Inc. - Schaumburg IL

International Classification:

C12N 1300

US Classification:

4351737, 219690, 219691, 219692, 219693, 422 22

Abstract:

A microwave device has a monolithic microwave integrated circuit (MMIC) disposed therein for applying microwave radiation to a microfluidic structure, such as a chamber, defined in the device. The microwave radiation from the MMIC is useful for heating samples introduced into the microfluidic structure and for effecting lysis of cells in the samples. Microfabrication techniques allow the fabrication of MMICs that perform heating and cell lysing of samples having volumes in the microliter to picoliter range.

US Patent:

20030064507, Apr 3, 2003

Filed:

Jul 26, 2002

Appl. No.:

10/206841

Inventors:

Sean Gallagher - Claremont CA, US
David Dorris - Austin TX, US
Lawrence Dues - Chandler AZ, US
Alan De La Cerda - Chandler AZ, US
Norb Simonson - Mesa AZ, US
Clifford Anderson - Tempe AZ, US
Phillip Franciskovich - Phoenix AZ, US
Peter Kahn - Phoenix AZ, US

International Classification:

C12M001/34

US Classification:

435/287200, 435/006000, 422/099000

Abstract:

The present invention provides microfluidic systems comprising microfluidic chambers and mixers, and methods of use. The microfluidic chambers of the present invention comprise a flexible membrane which provides efficient mixing of the solution therein. The present invention also provides a microfluidic chamber in fluidic communication with a micro-disk and a microfluidic chamber comprising a shim such that and a contiguous gap is present between a sample fluid and the chamber membrane. The microfluidic systems find use in the decrease in time for reactions occurring therein.

US Patent:

20030096283, May 22, 2003

Filed:

Sep 27, 2002

Appl. No.:

10/259532

Inventors:

Vi-En Choong - Chandler AZ, US
Song Shi - Phoenix AZ, US
George Maracas - Phoenix AZ, US
Sean Gallagher - Scottsdale AZ, US

Assignee:

Motorola Inc, A Corporation of the State of Delaware

International Classification:

C12Q001/68
C12M001/34

US Classification:

435/006000, 435/287200, 205/777500

Abstract:

This invention relates to apparatus and methods for detecting single base extension to an oligonucleotide array using electrochemical labels.

US Patent:

20030209432, Nov 13, 2003

Filed:

Feb 28, 2003

Appl. No.:

10/149319

Inventors:

Vi-En Choong - Chandler AZ, US
Sean Gallagher - Claremont CA, US
Mike Gaskin - Chandler AZ, US
Changming Li - Phoeniz AZ, US
George Maracas - Phoenix AZ, US
Song Shi - Phoenix AZ, US

International Classification:

G01N027/26

US Classification:

204/403130, 204/403140

Abstract:

This invention relates to the detection of molecular interactions between biological molecules. Specifically, the invention relates to electrical detection of interactions such as hybridization between nucleic acids or peptide antigen-antibody interaction using arrays of peptides or oligonucleotides. In particular, the invention relates to an apparatus and methods for detecting nucleic acid hybridization or peptide binding using electronic methods including AC impedance. In some embodiments, no electrochemical or other label moieties are used. In others, electrochemically active labels are used to detect reactions on hydrogel arrays, including genotyping reactions such as the single base extension reaction.

US Patent:

20060208199, Sep 21, 2006

Filed:

Mar 18, 2005

Appl. No.:

11/083768

Inventors:

Sean Gallagher - Claremont CA, US
Soham Mehta - Upland CA, US

International Classification:

G01J 1/58

US Classification:

250458100

Abstract:

A luminescent calibration device () is provided with the luminescent calibration device () having a housing () with a surface (). The housing () has a length (), a width (), and a thickness (). The housing () having a luminescent standard () disposed on the housing (). A method for calibrating and normalizing luminescent data across a sample and to normalize data from day to day variations is provided.

US Patent:

20100140090, Jun 10, 2010

Filed:

Dec 9, 2008

Appl. No.:

12/316183

Inventors:

Darius Kelly - Rancho Cucamonga CA, US
Sean Gallagher - Claremont CA, US

International Classification:

B01D 57/02
C25B 9/00

US Classification:

204461, 204612

Abstract:

A method and apparatus for expeditiously carrying out the preparation and imaging steps of the electrophoresis process. The apparatus of the invention includes a novel supporting surface comprising TEFLON AF that acts as a multi-function gel supporting surface which minimizes the probability of damaging the gel during transfer and provides a supporting surface that has an index of refraction lower than that of water and that of water based gel. When the TEFLON AF supporting surface is used to support the gel, or other mostly aqueous, fluorescent sample, the surface becomes a planar, aqueous core waveguide which traps the excitation light thereby increasing the efficiency of excitation.