Sean C O'Brien

US Patent:

7094791, Aug 22, 2006

Filed:

Jul 31, 2003

Appl. No.:

10/631887

Inventors:

Wieslaw M. Cholody - Frederick MD, US
Valentina Petukhova - Rockville MD, US
Sean O'Brien - Gaithersburg MD, US
Norman Ohler - New Market MD, US
Stanislaw Pikul - Germantown MD, US

Assignee:

Avalon Pharmaceuticals, Inc. - Germantown MD

International Classification:

A61K 31/445
C07D 207/00

US Classification:

514326, 514343, 514423, 514422, 548530, 548518, 546208, 5462784

Abstract:

Chemical agents of the general formula (I) and (II), such as derivatives of 3-hydroxy-pyrrole containing hydroxamic acid, and including salts thereof, that modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.

US Patent:

20050032794, Feb 10, 2005

Filed:

Jan 15, 2004

Appl. No.:

10/758521

Inventors:

Janak Padia - Germantown MD, US
Sean O'Brien - Gaithersburg MD, US
Jiemin Lu - Germantown MD, US
Stanislaw Pikul - Germantown MD, US

International Classification:

C07D265/36
C07D215/12
A61K031/538
A61K031/517
A61K031/498
A61K031/47
A61K031/165

US Classification:

514230500, 514266100, 514248000, 514249000, 514311000, 514310000, 514619000, 544105000, 544235000, 544283000, 544353000, 546139000, 546176000, 552292000

Abstract:

Diamine derivatives of quinones, and related compounds, including salts thereof, that modulate the levels of gene expression in cellular systems, such as cancer cells, are disclosed, along with methods for preparing such compounds and derivatives, as well as pharmaceutical compositions containing these compounds and derivatives as active ingredients. Methods of using these as compounds and derivatives as therapeutic agents are also described.

US Patent:

57513155, May 12, 1998

Filed:

Apr 16, 1996

Appl. No.:

8/632983

Inventors:

Cathie J. Burke - Rochester NY
R. Enrique Viturro - Rochester NY
John R. Andrews - Fairport NY
Narayan V. Deshpande - Penfield NY
Sean D. O'Brien - Victor NY

Assignee:

Xerox Corporation - Stamford CT

International Classification:

B41J 205

US Classification:

347 63

Abstract:

An ejector for a thermal ink-jet printhead includes a heating element defined on a main surface of a silicon heater chip. A cavity is disposed within the heater chip opposite the side of the heating element exposed to liquid ink. In one embodiment, the heating element is disposed on a narrow pillar which is surrounded by two elongated trenches. In another embodiment, the heating element is suspended over a cavity by narrow supports. In each case, the cavity reduces the thermal mass of the structure supporting the heating element and acts as an insulator to prevent excess heat from being dissipated into the body of the heater chip.

US Patent:

61469149, Nov 14, 2000

Filed:

Dec 7, 1998

Appl. No.:

9/207071

Inventors:

Cathie J. Burke - Rochester NY
Alan D. Raisanen - Sodus NY
Sean D. O'Brien - Victor NY

Assignee:

Xerox Corporation - Stamford CT

International Classification:

H01L 2100

US Classification:

438 21

Abstract:

An improved method is disclosed for forming heater elements for an ink jet printhead. The resistance is more closely controlled by doping a central heater region which is formed relatively thinner than the heavily doped heater regions which are used as the gate and contact areas. The thinner central region can doped relatively heavy in order to more accurately adjust the heater resistance. In another embodiment, the thin layer is amorphous silicon rather than the polysilicon to increase the latitude of the energy input.