Sean P O'Brien

US Patent:

7094791, Aug 22, 2006

Filed:

Jul 31, 2003

Appl. No.:

10/631887

Inventors:

Wieslaw M. Cholody - Frederick MD, US
Valentina Petukhova - Rockville MD, US
Sean O'Brien - Gaithersburg MD, US
Norman Ohler - New Market MD, US
Stanislaw Pikul - Germantown MD, US

Assignee:

Avalon Pharmaceuticals, Inc. - Germantown MD

International Classification:

A61K 31/445
C07D 207/00

US Classification:

514326, 514343, 514423, 514422, 548530, 548518, 546208, 5462784

Abstract:

Chemical agents of the general formula (I) and (II), such as derivatives of 3-hydroxy-pyrrole containing hydroxamic acid, and including salts thereof, that modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.

US Patent:

20130282284, Oct 24, 2013

Filed:

Apr 20, 2012

Appl. No.:

13/452047

Inventors:

Gail Vaucher - Las Cruces NM, US
Robert O. Brice - Las Cruces NM, US
Saba A. Luces - Las Cruces NM, US
Sean G. O'Brien - Las Cruces NM, US

International Classification:

G06F 19/00

US Classification:

702 3

Abstract:

A system to evaluate airborne hazards having at least one sensor module which detects atmospheric conditions and generates output signals representative of those atmospheric conditions. A model module receives the output from the sensor and generates a model output signal representative of a calculated wind flow and plume footprint, when applicable, over an area of interest. A display module receives the model output signal and visually displays the calculated wind flow and its effect on a plume if present in near real-time. The final system output is provided to authorized end users in near real-time.

US Patent:

20150229854, Aug 13, 2015

Filed:

Apr 13, 2015

Appl. No.:

14/684755

Inventors:

- Adelphi MD, US
Sean G. O'Brien - Las Cruces NM, US

Assignee:

U.S. ARMY RESEARCH LABORATORY ATTN: RDRL-LOC-I - Adelphi MD

International Classification:

H04N 5/357
G06T 5/00

Abstract:

A method for image processing comprising providing an opening for entrance of light; the light being capable of being formed into an image; providing at least one optical element in an optical train configured to focus light; providing a variable aperture operatively associated with the at least one optical element; the variable aperture being placed in the optical train at an image plane and comprising mask settings for shielding portions of the light; providing an imager; providing at least one processor operatively connected to the variable aperture and imager; the at least one processor configured to control the passage of the light through the variable aperture; selectively masking portions of light using the mask settings of the variable aperture; obtaining image results using the settings; comparing image results obtained by the mask settings, and determining the phase correction that provides the optimal image results.

US Patent:

20140125860, May 8, 2014

Filed:

Nov 2, 2012

Appl. No.:

13/667048

Inventors:

- Adelphi MD, US
Sean Gerard O'Brien - Las Cruces NM, US

Assignee:

U.S. ARMY RESEARCH LABORATORY ATTN: RDRL-LOC-I - Adelphi MD

International Classification:

H04N 5/235

US Classification:

348349

Abstract:

A method and system for image processing comprising an opening for entrance of light for forming an image by the system; at least one optical element through which the light passes; a variable aperture operatively associated with the at least one optical element placed in the optical train at an image plane and comprising a plurality of settings comprising first mask settings for shielding portions of the light and second mask settings for selectively masking portions of the light that pass through the first mask settings; an imager, the at least one processor being operatively connected to the variable aperture and imager for controlling the passage of the light through the variable aperture by selecting one of plurality of first mask settings and associated second mask settings, obtaining image results using the settings, comparing image results obtained by the respective mask settings, and determining the optimal first mask setting.