Sharon L Li

US Patent:

6596772, Jul 22, 2003

Filed:

Aug 25, 2000

Appl. No.:

09/645879

Inventors:

Ping Huang - Mountain View CA
Chung Chen Wei - Foster City CA
Peng Cho Tang - Moraga CA
Chris Liang - Sunnyvale CA
John Ramphal - Union City CA
Bahija Jallal - Menlo Park CA
John Biltz - Newark CA
Sharon Li - Los Altos CA
Matt Mattson - Santa Clara CA
Gerald McMahon - Kenwood CA
Marcel Koenig - Burlingame CA

Assignee:

Sugen, Inc. - South San Francisco CA

International Classification:

A61K 3105

US Classification:

514602, 514613, 514715, 514730, 544106, 544162, 544170, 564 80, 564 84, 564100, 564123, 564430, 568 21, 568 38, 568579, 568608

Abstract:

The invention relates to trifluoromethyl sulfonyl and trifluoromethyl sulfonamido compounds and the physiologically acceptable salts and the prodrugs thereof. These compounds are expected to modulate the activity of protein tyrosine enzymes which are related to cellular signal transduction, in particular, protein tyrosine phosphatase, and therefore are expected to be useful in the prevention and treatment of disorders associated with abnormal protein tyrosine enzyme related cellular signal transduction such as cancer, diabetes, immuno-modulation, neurologic degenerative diseases, osteoporosis and infectious diseases. The invention also relates to the use of compounds containing fluoromethyl sulfonyl groups as phosphate mimics. These mimics may be used to inhibit, regulate or modulate the activity of a phosphate binding protein in a cell.