Stacy E Wright

US Patent:

6509104, Jan 21, 2003

Filed:

Dec 5, 2000

Appl. No.:

09/730098

Inventors:

Zhi Heng Huang - San Ramon CA
William F. McDonald - Utica OH
Stacy C. Wright - Flint MI
Andrew C. Taylor - Ann Arbor MI

Assignee:

Michigan Biotechnology Institute - Lansing MI

International Classification:

B32B 2708

US Classification:

4284744, 4284111, 4284235, 427 21, 427322, 427331, 128DIG 22, 523112, 525 50, 525 541, 525 542, 525 5422

Abstract:

An article having a non-thrombogenic surface and a process for making the article are disclosed. The article is formed by (i) coating a polymeric substrate with a crosslinked chemical combination of a polymer having at least two amino substituted side chains, a crosslinking agent containing at least two crosslinking functional groups which react with amino groups on the polymer, and a linking agent containing a first functional group which reacts with a third functional group of the crosslinking agent, and (ii) contacting the coating on the substrate with an antithrombogenic agent which covalently bonds to a second functional group of the linking agent. In one example embodiment, the polymer is a polyamide having amino substituted alkyl chains on one side of the polyamide backbone, the crosslinking agent is a phosphine having the general formula (A) P wherein A is hydroxyalkyl, the linking agent is a polyhydrazide and the antithrombogenic agent is heparin.