Stephen M Epstein

US Patent:

6595979, Jul 22, 2003

Filed:

Oct 23, 2001

Appl. No.:

09/999765

Inventors:

Stephen Epstein - Rockville MD
Shmuel Fuchs - Rockville MD
Ran Kornowski - Ramat-Hasharon, IL

Assignee:

Myocardial Therapeutics, Inc. - San Diego CA

International Classification:

A61M 3100

US Classification:

604506, 604522

Abstract:

Methods for aspiration and filtering of a bodily fluid containing undesired components are provided and for treatment of the bodily fluids in a sterile environment in preparation for reinjection of treated aspirate into a donor subject. The invention methods are particularly designed to facilitate transfection of aspirated cells with angiogenesis promoting molecules without danger to the technician or the donor prior to reinjection of the treated cells, either percutaneously or via a surgical opening via a catheter or injection needle. A pressure actuator attached to the sterile container is used to express treated fluids in precisely controlled volumes. The invention methods include delivery of treated fluids using a hand-held device with audible cues that correspond to an operator-selected injection volume and/or audible cues that correspond to needle penetration depth selected by the operator.

US Patent:

D478668, Aug 19, 2003

Filed:

Jan 27, 2003

Appl. No.:

29/174888

Inventors:

Stephen Todd Epstein - Newtown PA 18940

International Classification:

2401

US Classification:

D24187

US Patent:

6682728, Jan 27, 2004

Filed:

Oct 13, 1993

Appl. No.:

08/136113

Inventors:

Toren Finkel - Bethesda MD
Raul G. Guzman - Rockville MD
Ronald G. Crystal - Potomac MD
Stephen E. Epstein - Rockville MD

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

A01N 6300

US Classification:

424 932, 424 936, 4353201

Abstract:

The present invention provides a method of selectively expressing DNA in neointimal cells in an injured blood vessel of a subject comprising administering a replication-deficient recombinant adenovirus which functionally encodes the DNA to the blood vessel at the site of injury, such that the adenovirus remains at the site of injury for a time sufficient for the adenovirus to selectively infect neointimal cells and thereby selectively express the DNA in neointimal cells. In particular, the invention provides administering a replication-deficient recombinant adenovirus which functionally encodes a DNA encoding a protein or an antisense ribonucleic acid. This method can be used to treat restenosis and, relatedly, prevent neointimal cell proliferation.

US Patent:

6835193, Dec 28, 2004

Filed:

Oct 23, 2001

Appl. No.:

10/000851

Inventors:

Stephen Epstein - Rockville MD
Shmuel Fuchs - Rockville MD
Ran Kornowski - Ramat-Hasharon, IL

Assignee:

Myocardial Therapeutics, Inc. - La Jolla CA

International Classification:

A61M 3100

US Classification:

604507, 604117, 60416401

Abstract:

A flexible tissue injection catheter is used to accomplish injections at a precisely controlled depth of precisely controlled volumes of a therapeutic or diagnostic agent into an interior body cavity, such as the epicardium or myocardium of the heart. In one embodiment, the invention method includes repeated injections at spaced intervals along the myocardium or epicardium of sterile fluid containing autologous bone marrow aspirate to promote angiogenesis. For myocardial injection, depth penetration is controlled by using a catheter that allows the operator to control depth penetration by means of an adjustable needle stop attached to the catheter handle. In another embodiment depth penetration during epicardial injections is controlled by use of an injection catheter having an operator-controlled adjustable needle stop that produces a sensible signal, such as a visible or audible signal, marking each increment of needle tip exposed by operation of the adjustable needle stop.

US Patent:

7079884, Jul 18, 2006

Filed:

Dec 19, 2003

Appl. No.:

10/739369

Inventors:

Stephen T. Epstein - Newtown PA, US

International Classification:

A61B 5/04

US Classification:

600391, 600392, 600393

Abstract:

An electrode system and the method of arranging the electrodes on the skin of a patient. The electrode system contains a plurality of electrode pads. At least some of the electrode pads have a convex side edge of a predetermined radius of curvature. At least some of the electrode pads have a concave side edge with the same predetermined radius of curvature. When applied to a patient's skin, two electrode pads are placed in adjacent abutment. The concave side edge of one electrode pad receives the convex side edge of the adjacent electrode pad. This produces a gapless adjoining connection between electrode pads that can be maintained throughout a wide range of orientations.

US Patent:

7097832, Aug 29, 2006

Filed:

Mar 30, 2000

Appl. No.:

09/868411

Inventors:

Ran Kornowski - Ramat hasharon IL, US
Shmuel Fuchs - Rockville MD, US
Stephen E. Epstein - Rockville MD, US
Martin B. Leon - New York NY, US

Assignee:

Myocardial Therapeutics, Inc. - San Diego CA

International Classification:

A01N 63/00
C12N 5/00
C12N 5/06

US Classification:

424 937, 435384, 435372

Abstract:

A method of treating cardiac or myocardial conditions comprises the administration of an effective amount of autologous bone marrow. The bone marrow may optionally be stimulated and/or administered in combination with a pharmaceutical drug, protein, gene or other factor or therapy that may enhance bone marrow production of angiogenic growth factors and/or promote endothelial cell proliferation or migration or blood vessel formation.

US Patent:

7100838, Sep 5, 2006

Filed:

Jun 17, 2004

Appl. No.:

10/869772

Inventors:

Stephen T. Epstein - Newtown PA, US

International Classification:

A47G 21/18
A61J 15/00

US Classification:

239 33, 239 24, 239 1, 239 12, 239DIG 11

Abstract:

A novelty drinking straw assembly and its method of construction. The drinking straw assembly has a straw tube through which fluid is drawn. A first magnet is disposed within the straw tube. The first magnet is part of a rotor mechanism that rotates when fluid is drawn through the straw tube. A novelty object is disposed around a section of the straw tube. The novelty object has at least one second magnet. The magnets in the novelty object interact with the first magnet contained within the straw tube. This magnetic field interaction causes the novelty object to move about the straw tube whenever the straw is in use and the first magnet is rotating within the straw tube.

US Patent:

7130674, Oct 31, 2006

Filed:

Feb 17, 2004

Appl. No.:

10/778816

Inventors:

Stephen T. Epstein - Newtown PA, US

International Classification:

A61B 5/04

US Classification:

600391, 607152

Abstract:

An electrode configuration and its method of manufacture. The electrode includes a pad of material having a first end, an opposite second end, a top surface and a conductive bottom surface. At least one fold line is provided in the pad of material between the first end and the second end. The pad of material is folded over along the fold lines to create a folded form. The folded form has a flap element that extends from one of the folds to the second end of the pad of material. The flap element enables a clip to attach to the pad of material without peeling the remainder of the pad of material from a person's skin.