Detectably-labeled compounds of formula (I) wherein A,B,C,D,E,F,R,X,Y and Z have any of the meanings given in the specification, and their pharmaceutically acceptable salts, are useful in competitive assays to assay for the presence of 2 receptors. Also disclosed are pharmaceutical compositions containing such a compound of formula (I), methods for their use and intermediates useful for preparing such compounds of formula (I).
Methods And Compositions Utilizing An Alternative Splice Variant Of The Sigma-1 Receptor
Kenneth T. Wheeler - Winston-Salem NC, US Robert H. Mach - Winston-Salem NC, US Steven Childers - Winston-Salem NC, US Gregory Shelness - Winston-Salem NC, US Li-Ming Wang - Bethesda MD, US
A new variant of the sigma-1 (σ)receptor is useful in screening compounds useful in the imaging and treatment of proliferative masses (i. e. , tumors). This new variant, named sigma— (σ) finds particular use in the non-invasive diagnosis of cancer and more particularly in the diagnosis of proliferative cancer cells.
2 Step Process For Preparing Biologically Active Tropane Derivatives And Starting Material Therefore
Huw M. L. Davies - Clemmons NC Elie Saikali - Winston-Salem NC Steven R. Childers - Winston-Salem NC
Assignee:
Wake Forest University - Winston-Salem NC
International Classification:
C07D45102
US Classification:
546124
Abstract:
Preparation of biologically active tropane derivatives of novel configurations. The compounds are prepared by decomposing vinyldiazomethanes in the presence of pyrroles to provide a bicyclic ring containing the basic tropane ring system which is then reacted with an aryl Grignard reagent in the presence of a copper (I) or (II) salt to provide 3-aryl-tropane derivatives.
.Sigma.-2 Receptors As Biomarkers Of Tumor Cell Proliferation
Robert H. Mach - Winston-Salem NC Kenneth T. Wheeler - Winston-Salem NC Biao Yang - Winston-Salem NC Steven R. Childers - Winston-Salem NC
Assignee:
Wake Forest University - Winston-Salem NC
International Classification:
A61K 5100 A61M 3614
US Classification:
424 165
Abstract:
The invention provides detectably-labeled compounds of formula (I): ##STR1## wherein A, B, C, D, E, F, R, X, Y and Z have any of the meanings given in the specification, and their pharmaceutically acceptable salts, are useful in competitive assays to assay for the presence of. sigma. 2 receptors. Also disclosed are pharmaceutical compositions containing such a compound of formula (I), methods for their use and intermediates useful for preparing such compounds of formula (I).
Huw M. L. Davies - Clemmons NC Elie Saikali - Winston-Salem NC Steven R. Childers - Winston-Salem NC
Assignee:
Wake Forest University - Winston-Salem NC
International Classification:
C07D45106 C07D45104 A61K 3146
US Classification:
514304
Abstract:
Preparation of biologically active tropane derivatives of novel configurations. The compounds are prepared by decomposing vinyldiazomethanes in the presence of pyrroles to provide a bicyclic ring containing the basic tropane ring system which is then reacted with an aryl Grignard reagent in the presence of a copper (I) or (II) salt to provide 3-aryltropane derivatives.
Process For Blocking 5-Ht And Dopamine Uptake With Biologically Active Tropane Derivatives
- Atlanta GA, US - Winston-Salem NC, US Thomas J. Martin - Walkertown NC, US Steven R. Childers - Winston-Salem NC, US
International Classification:
C07C 229/46 A61K 31/216 A61K 45/06
Abstract:
The disclosure relates to cyclopropyl derivatives and methods of use. In some embodiments, the disclosure relates to methods of managing medical disorders with pharmaceutical compositions disclosed herein administered to subject in need thereof. In certain embodiments, the disclosure relates to methods of managing mental disorders, mood disorders, pain, and fibromyalgia and related conditions with pharmaceutical compositions disclosed herein.
The only time it must be reported is when a child under 18 dies from it."Because of its classification, it can be hard to have data on the flu," Steven Childers, a registered nurse at the Ford County Health Department said in an interview Monday. "However, I do know of one case of influenza A this
Alicia Kolde, Jessica Tremblay, Andrew Mulkey, Nicole Niehues, Thomas Musick, Taylor Bozarth, April May, Robert Platt, Reba Cleave, Bree Rindt, Paige Carrier, Daniel Shumate
Greg Mcdowell, Denise Rhoney, Janet Pennington, Michael Dellinger, Joyce Fulton, Chris Hoyle, Lisa Hollifield, Kimberly Stokely, Laura Clay, Kenneth Allen, Donna Miller, Eddie Greene
Raymond Jump, Marty Samples, Kim Coleman, Timothy Howell, Brook Walters, John Smith, Janet Blagg, Eric Clinton, Sherry Parsons, David Cook, Mike Wilson