White River Rural HealthArcare 400 Hwy 64 E, Augusta, AR 72006 (870)3472508 (phone), (870)3475556 (fax)
Education:
Medical School University of Arkansas College of Medicine at Little Rock Graduated: 1980
Languages:
English Spanish
Description:
Dr. Collier graduated from the University of Arkansas College of Medicine at Little Rock in 1980. He works in Augusta, AR and specializes in Family Medicine. Dr. Collier is affiliated with North East Arkansas Baptist Memorial Hospital.
Ee Lui Ang - Singapore, SG Oscar Alvizo - Fremont CA, US Behnaz Behrouzian - Sunnyvale CA, US Michael Clay - Menlo Park CA, US Steven Collier - Lexington MA, US Ellen Eberhard - Fallbrook CA, US Fan Jaslyn Fu - Singapore, SG Shiwei Song - Singapore, SG Derek Smith - Singapore, SG Magnus Widegren - Craigavon, GB Robert Wilson - San Francisco CA, US Junye Xu - Singapore, SG Jun Zhu - Chandler AZ, US
The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenyl-methyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
Engineered Imine Reductases And Methods For The Reductive Animation Of Ketone And Amine Compounds.
CHEN Haibin - SG, SG Steven J. Collier - Lexington MA, US Jovana NAZOR - Santa Clara, US Joly SUKUMARAN - SG, SG Derek SMITH - Singapore, SG Jeffrey C. MOORE - Westfield NJ, US Gregory HUGHES - Scotch Plains NJ, US Jacob JANEY - New York NY, US Gjalt HUISMAN - San Carlos CA, US Scott NOVICK - Palo Alto CA, US Nicholas AGARD - San Francisco CA, US Oscar ALVIZO - Freemont CA, US Gregory COPE - Menlo Park CA, US Wan Lin YEO - Singapore, SG Stephanie NG - Redwood City CA, US
The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
Biocatalysts And Methods For The Synthesis Of Armodafinil
- Redwood City CA, US Oscar Alvizo - Fremont CA, US Behnaz Behrouzian - Sunnyvale CA, US Michael D. Clay - Menlo Park CA, US Steven J. Collier - Concord MA, US Ellen D. Eberhard - Fallbrook CA, US Fu Fan - Singapore, SG Shiwei Song - Singapore, SG Derek J. Smith - Singapore, SG Magnus Widegren - Craigavon, GB Robert Wilson - Meldreth, GB Junye Xu - Singapore, SG Jun Zhu - Chandler AZ, US
International Classification:
C12N 9/02 C12P 11/00 C12P 41/00 C12P 13/02
Abstract:
The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
Engineered Imine Reductases And Methods For The Reductive Amination Of Ketone And Amine Compounds
- Redwood City CA, US Steven J. Collier - Concord MA, US Jovana Nazor - Milpitas CA, US Joly Sukumaran - Singapore, SG Derek Smith - Singapore, SG Jeffrey C. Moore - Westfield NJ, US Gregory Hughes - Scotch Plains NJ, US Jacob Janey - New York NY, US Gjalt W. Huisman - Redwood City CA, US Scott J. Novick - Palo Alto CA, US Nicholas J. Agard - San Francisco CA, US Oscar Alvizo - Fremont CA, US Gregory A. Cope - Menlo Park CA, US Wan Lin Yeo - Singapore, SG Stefanie Ng Minor - Redwood City CA, US
The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
Ketoreductase Polypeptides For The Preparation Of Phenylephrine
- Redwood City CA, US Steven J. Collier - Concord MA, US Hans-Georg Joerg Hennemann - Bedburg, DE Seong Ho Oh - Singapore, SG Wenjuan Zha - Singapore, SG
International Classification:
C12N 9/04 A61K 31/137 C12P 13/00
Abstract:
The disclosure relates to engineered ketoreductase polypeptides and processes of using the polypeptides for production of phenylephrine.
- REDWOOD CITY CA, US John M. Gruber - El Dorado Hills CA, US Emily Mundorff - Garden City NY, US Gjalt W. Huisman - Redwood City CA, US Steven J. Collier - Concord MA, US
International Classification:
C12P 17/00 C12N 9/04 C12P 13/00
Abstract:
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
Biocatalysts And Methods For Synthesizing Derivatives Of Tryptamine And Tryptamine Analogs
- Redwood City CA, US Derek J. Smith - Singapore, SG Michael A. Crowe - Singapore, SG Shiwei Song - Singapore, SG Steven J. Collier - Concord MA, US
International Classification:
C12N 9/10 C12P 17/10
Abstract:
The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.
- Redwood City CA, US Steven J. Collier - Concord MA, US Joly Sukumaran - Singapore, SG Wan Lin Yeo - Singapore, SG Oscar Alvizo - Fremont CA, US Ee Ling Teo - Mauchline East Ayrshire, GB Robert J. Wilson - San Francisco CA, US Junye Xu - Singapore, SG
Sage Therapeutics
Senior Director, Process Development
Johnson Matthey Fine Chemicals Aug 2016 - Jan 2018
Director of R and D and New Technologies
Johnson Matthey Mar 2013 - Aug 2016
Director of R and D and Manufacturing
Nanyang Technological University 2010 - Sep 2013
Adjunct Associate Professor, Department of Chemistry
Codexis, Inc. Feb 2009 - Dec 2012
Director of R and D and General Manager , Codexis Laboratories Singapore
Education:
University of Liverpool 1994 - 1997
Doctorates, Doctor of Philosophy, Organic Chemistry
University of Liverpool 1990 - 1994
Bachelors, Bachelor of Science, Chemistry
Skills:
Chemistry Organic Synthesis R&D Pharmaceutical Industry Biotechnology Design of Experiments Medicinal Chemistry Analytical Chemistry Technology Transfer Biocatalysis Team Leadership Lifesciences Process Simulation Chromatography Hplc Organic Chemistry Drug Discovery Purification Research and Development Drug Development Life Sciences Gmp Nmr Protein Chemistry Innovation Molecular Biology Lc Ms Liquid Chromatography Mass Spectrometry Nuclear Magnetic Resonance Process Development High Performance Liquid Chromatography Project Management
Certifications:
Fellow of the Royal Society of Chemistry (Frsc) Certified International Project Manager (Cipm) Chartered Scientist (Csci) European Chemist (Eurchem) Chartered Chemist (Cchem) and Member of the Royal Society of Chemistry (Mrsc)
Austin, TX Carlsbad, NM Alamogordo, NM Houston, TX Las Cruces, NM West Lafayette, IN Schenectady, NY Albuquerque, NM Baytown, TX Oklahoma City, OK Nashville, TN Leesburg, VA Ashburn, VA Abilene, TX New York, NY
Work:
Milsoft Utility Solutions - Electrical Engineer; High Tech Executive (2006) Rasco Tempo Store - Men's Dept Mgr (1969-1971) Coronado Glass Co - Glazier (1967-1968) Rose Gravel Co - Equipt Operator (1979-1971) Jackson Drug Store - Soda Jerk, Deliveries (1968-1970) Houston Lighting & Power Co - Cooperative Program Student Engineer (1972-1976) Houston Lighting & Power Company - Engineer (1976-1976) Purdue Electric Power Institute - Research Assistant (1976-1977) University of Houston - Teaching Assistant (1973-1976) Power Technologies, Inc - Analytical Engineer (1977-1978) Sandia National Laboratories - Member of Technical Staff (1978-1979) C H Guernsey & Company - VP, Board Member (1979-1989) Cap Rock Electric Cooperative - SVP Energy Resources & Government Affairs (1999-1995) C H Guernsey & Company - Director, CHG Strategy Group (1995-1997) Institute for Management Development & Change - Managing Partner (1997-1999) Util-LINK LLC - President & CEO (1999-2001) National Rural Telecommunications Cooperative - VP Business Development (2001-2006)
Education:
US Military Academy; New Mexico State University; University of Houston; Purdue University
About:
MarriedFather of 6 daughters & 1 son
Bragging Rights:
Seven wonderful, successful, unique children, married twice, have had 12 jobs as a professional or executive in my career, helping to keep Austin weird
Steven Collier
Lived:
Alamogordo, NM Carlsbad, NM West Point, NY Baytown, TX Las Cruces, NM Houston, TX West Lafayette, IN Schenectady, NY Albuquerque, NM Oklahoma City, OK Austin, TX Nashville, TN Leesburg, VA Ashburn, VA Abilene, TX
Work:
Milsoft Utility Solutions - VP Marketing & Business Development (2006) National Rural Telecommunications Cooperative - VP Competitive Intelligence (2001-2006) Util-LINK LLC - President & CEO (2000-2001) Institute for Management Development & Change - Managing Partner (1998-2001) C H Guernsey & Company - Director, CHG Strategy Group (1996-1998) University of Houston - VP Energy Resources & Government Affairs (1989-1996) C H Guernsey & Company - SVP (1980-1989) Sandia National Laboratories - Member of Technical Staff (1979-1980) Power Technologies, Inc - Analytical Consultant (1978-1979) CenterPoint Energy - Student Engineer / Junior Engineer (1973-1978)
Education:
Monterrey Elementary, Eisenhower Junior High, Carlsbad Mid High School, Carlsbad Senior High School, US Military Academy, New Mexico State University - Electrical Engineering, University of Houston - Electrical Engineering, Purdue University - Electrical Engineering
Relationship:
Married
Steven Collier
Work:
Brookshire Brothers - Sacker (2011-2012)
Relationship:
In_a_relationship
About:
Hi, I'm steven. I'm a gamer, fighter and various other things. :)
Austin, TXVP Business Development at Milsoft Utility Solutio... Past: VP Competitive Intelligence at National Rural Telecommunications Cooperative, President &... Born in Alamogordo, NM.
Grew up in Carlsbad, NM.
One sister, Denise, married to Dan Williams, living in Corona, NM.
6'4" tall. 190 lbs.
Married to Allison... Born in Alamogordo, NM.
Grew up in Carlsbad, NM.
One sister, Denise, married to Dan Williams, living in Corona, NM.
6'4" tall. 190 lbs.
Married to Allison Leigh Conley.
SEVEN CHILDREN! Rachel, Joel, Lori, Ginna, Zoe, twins Harper & Raine
One son-in-law, Mike Wheeler & two granddaughters, Victoria...
Bainbridge-Guilford High School Bainbridge NY 1989-1993
Community:
Bridget Winn, David Louden, Jessica Wright, Kristie Dietrich, Lisa Wayman, Christi Turtur, Scott Leach, Jessica Birdsall, Jennifer Hartwell, Robin Rusweiler, Franklin Devries