Steven Lee Reed

US Patent:

6338852, Jan 15, 2002

Filed:

Mar 13, 1997

Appl. No.:

08/818111

Inventors:

Steven G. Reed - Bellevue WA
Yasir A. W. Skeiky - Seattle WA
Davin C. Dillon - Redmond WA
Antonio Campos-Neto - Bainbridge Island WA
Raymond Houghton - Bothell WA
Thomas S. Vedvick - Federal Way WA
Daniel R. Twardzik - Bainbridge Island WA

Assignee:

Corixa Corporation - Seattle WA

International Classification:

A61K 3904

US Classification:

4242481, 424 92, 435 7, 4351723, 435320, 4353207, 530350

Abstract:

Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.

US Patent:

6344550, Feb 5, 2002

Filed:

Apr 17, 1998

Appl. No.:

09/062451

Inventors:

Tony N. Frudakis - Seattle WA
John M. Smith - Everett WA
Steven G. Reed - Bellevue WA

Assignee:

Corixa Corporation - Seattle WA

International Classification:

C07H 2104

US Classification:

536 235, 4352523, 43525411, 4353201, 435325

Abstract:

Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.

US Patent:

6350456, Feb 26, 2002

Filed:

Apr 7, 1998

Appl. No.:

09/056556

Inventors:

Steven G. Reed - Bellevue WA
Yasir A. W. Skeiky - Seattle WA
Davin C. Dillon - Redmond WA

Assignee:

Corixa Corporation - Seattle WA

International Classification:

A61K 304

US Classification:

4242481, 4241681, 435 6, 435 71, 4352521, 4352523, 4352531, 4353201, 435325

Abstract:

Compositions and methods for treatment and vaccination against tuberculosis are disclosed. In one aspect the compositions provided include at least two polypeptides that contain an immunogenic portion of a antigen or at least two DNA molecules encoding such polypeptides. In a second aspect, the compositions provided include a fusion protein comprising at least two polypeptides that contain an immunogenic portion of a antigen. Such compositions may be formulated into vaccines and/or pharmaceutical compositions for immunization against infection, or may be used for the diagnosis of tuberculosis.

US Patent:

6365165, Apr 2, 2002

Filed:

Oct 30, 1998

Appl. No.:

09/183861

Inventors:

Steven G. Reed - Bellevue WA
Antonio Campos-Neto - Bainbridge Island WA
John R. Webb - Manotick, CA
Davin C. Dillon - Redmond WA
Yasir A. W. Skeiky - Seattle WA

Assignee:

Corixa Corporation - Seattle WA

International Classification:

A61K 39008

US Classification:

4242691, 4241841, 4242651, 424450, 424 852, 514 12, 514 44, 514 2

Abstract:

Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.

US Patent:

6365348, Apr 2, 2002

Filed:

Jul 17, 1998

Appl. No.:

09/118554

Inventors:

Steven G. Reed - Bellevue WA
Jiangchun Xu - Bellevue WA

Assignee:

Corixa Corporation - Seattle WA

International Classification:

C12Q 168

US Classification:

435 6, 436 64

Abstract:

Compounds and methods for the diagnosis of breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of a breast tumor protein. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of breast cancer. Nucleic acid sequences for preparing probes, primers, and polypeptides are also provided.

US Patent:

6375955, Apr 23, 2002

Filed:

Feb 12, 1998

Appl. No.:

09/022765

Inventors:

Steven G. Reed - Bellevue WA
Antonio Campos-Neto - Bainbridge Island WA
John R. Webb - Manotick, CA
Davin C. Dillon - Issaquah WA
Yasir A. W. Skeiky - Bellevue WA
Ajay Bhatia - Seattle WA
Peter Probst - Seattle WA

Assignee:

Corixa Corporation - Seattle WA

International Classification:

A61K 39008

US Classification:

4242691, 4242651, 4241841, 930210, 530300, 530350

Abstract:

Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.

US Patent:

6379951, Apr 30, 2002

Filed:

Jul 17, 1998

Appl. No.:

09/118627

Inventors:

Steven G. Reed - Bellevue WA
Jiangchun Xu - Bellevue WA

Assignee:

Corixa Corporation - Seattle WA

International Classification:

C07H 2104

US Classification:

435325, 536 235, 536 231, 43525233, 4352528, 4352542, 4353201, 435352, 435358, 435363, 435365, 435366

Abstract:

Compounds and methods for treating breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of a breast tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of breast cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.

US Patent:

6410507, Jun 25, 2002

Filed:

Jul 2, 1999

Appl. No.:

09/346327

Inventors:

Steven G. Reed - Bellevue WA
Jiangchun Xu - Seattle WA
Davin C. Dillon - Redmond WA

Assignee:

Corixa Corporation - Seattle WA

International Classification:

A61K 3818

US Classification:

514 2, 514 12, 530350, 530351, 530399

Abstract:

Compounds and methods for the treatment and diagnosis of breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of a breast tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of breast cancer comprising such polypeptides, or polynucleotides encoding such polypeptides, are also provided, together with polynucleotides for preparing the inventive polypeptides.