Steven R Weiss

US Patent:

20070049952, Mar 1, 2007

Filed:

Aug 10, 2006

Appl. No.:

11/463675

Inventors:

Steven Weiss - Haverford PA, US

International Classification:

A61B 17/04

US Classification:

606144000

Abstract:

A method and apparatus for repairing the heart's mitral valve by using anatomic restoration without the need to stop the heart, use a heart-lung machine or making incisions on the heart. The method involves inserting a leaflet clamp through the heart's papillary muscle from which the leaflet has been disconnected, clamping the leaflet's free end and then puncturing the leaflet. One end of a suture is then passed through the hollow portion of the clamp, while the other end of the suture is maintained external to the heart. The clamp is then removed and the suture's two ends are fastened together with a securement ring/locking cap assembly to the heart wall exterior, thereby reconnecting the leaflet to the corresponding papillary muscle. The introduction of the clamp, puncturing of the leaflet, passage of the suture therethrough and removal of the clamp can be conducted a plurality of times before each suture's two ends are fastened to the securement ring/locking cap assembly.

US Patent:

51696371, Dec 8, 1992

Filed:

Apr 2, 1991

Appl. No.:

7/679569

Inventors:

Robert P. Lenk - Lambertville NJ
Michael W. Fountain - Griggstown NJ
Andrew S. Janoff - Yardley PA
Mircea C. Popescu - Plainsboro NJ
Steven J. Weiss - Hightstown NJ
Richard S. Ginsberg - Monroe Township, Salem County NJ
Marc J. Ostro - Griggstown NJ
Sol M. Gruner - Lawrenceville NJ

Assignee:

The Liposome Company, Inc. - Princeton NJ

International Classification:

A61K 3722
A61K 3700
A61K 3170
A61K 3165
A61K 3143

US Classification:

424450

Abstract:

A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same and X-ray diffraction methods for identifying the same. SPLVs are characterized by lipid bilayers enclosing aqueous compartments containing one or more entrapped solutes, the concentration of such solutes in each aqueous compartment being substantially equal to the emunization of solutes used to prepare the SPLVs. The bilayers of SPLVs are substantially non-compressed. SPLVs are stable during storage and can be used in vivo for the sustained release of compounds and in the treatment of disease.

US Patent:

50304534, Jul 9, 1991

Filed:

Oct 12, 1984

Appl. No.:

6/660573

Inventors:

Robert P. Lenk - Lambertville NJ
Michael W. Fountain - Griggstown NJ
Andrew S. Janoff - Yardley PA
Mircea C. Popescu - Plainsboro NJ
Steven J. Weiss - Hightstown NJ
Richard S. Ginsberg - Monroe Township, NJ
Marc J. Ostro - Griggstown NJ
Sol M. Gruner - Lawrenceville NJ

Assignee:

The Liposome Company, Inc. - Princeton NJ

International Classification:

A61K 3722

US Classification:

424450

Abstract:

A new and substantially improved type of lipid vesicle, called stable plurilamellar vesicles (SPLVs), are described, as well as the process for making the same and X-ray diffraction methods for identifying the same. SPLVs are characterized by lipid bilayers enclosing aqueous compartments containing one or more entrapped solutes, the concentration of such solutes in each aqueous compartment being substantially equal to the concentration of solutes used to prepare the SPLVs. The bilayers of SPLVs are substantially non-compressed. SPLVs are stable during storage and can be used in vivo for the sustained release of compounds and in the treatment of disease.