Terry L Morgan

US Patent:

20110171216, Jul 14, 2011

Filed:

Sep 9, 2009

Appl. No.:

13/062942

Inventors:

Phillip R. Streeter - Portland OR, US
Markus Grompe - Portland OR, US
Karin M. Hardiman - Portland OR, US
Brett C. Sheppard - Portland OR, US
Christopher L. Corless - Portland OR, US
Terry K. Morgan - Portland OR, US

International Classification:

A61K 39/395
G01N 33/53
C12N 9/96
C12N 5/10
C12N 5/16
C12N 5/02
C12N 15/63
C07K 16/18
C07H 21/04

US Classification:

4241331, 4241411, 435 71, 435188, 435325, 435326, 435375, 435378, 4353201, 5303873, 5303881, 5303913, 5303917, 536 2353

Abstract:

Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic cancer cells or precancerous pancreatic cancer cells. Humanized forms of these antibodies, functional fragments of these antibodies, and hybridomas producing these antibodies are also disclosed. The antibodies can be conjugated to an effector molecule, such as a detectable marker, a therapeutic agent, or a toxin. The antibodies can be used for in vitro or in vivo pancreatic cancer diagnosis or disease monitoring via detection of pancreatic cancer cells or the pancreatic cancer cell surface antigen. Methods of treating a pancreatic cancer by administration of the antibodies are also disclosed.