Thomas P Gallagher

US Patent:

57920745, Aug 11, 1998

Filed:

Mar 5, 1996

Appl. No.:

8/611225

Inventors:

David Turkel - Punta Gorda FL
Frank A. Scarfone - Miramar FL
Matthew S. Solar - Cooper City FL
Herbert Cohen - Fort Lauderdale FL
David P. Gordon - Stamford CT
Thomas A. Gallagher - Stamford CT

International Classification:

A61B 500

US Classification:

600569

Abstract:

A protected microbiological sampling brush assembly includes a sampling brush mounted on the distal end of a control wire, an inner catheter which houses the brush, an outer catheter which houses the inner catheter, and an elastomeric tip which is rigidly attached to the distal end of the outer catheter and which has a weakened end. The proximal ends of the control wire and catheters are coupled to a handle for independently moving the control wire, the inner catheter, and the outer catheter relative to each other. The weakened end of the elastomeric tip is preferably a slit which defines lips which are parted when the distal end of the inner catheter is moved distally against the elastomeric tip to allow the inner catheter to pass therethrough. When the inner catheter is moved proximally relative to the outer catheter, the lips of the elastomeric tip close to protect the inner catheter (and the sampling brush) from contamination. Easy to use handles which are attached to the proximal ends of the control wire, the inner catheter, and the outer catheter are disclosed.

US Patent:

20180325461, Nov 15, 2018

Filed:

May 27, 2016

Appl. No.:

15/577526

Inventors:

- Evanston IL, US
YONG I. JEONG - CARY IL, US
DAVID MANGLANO - PALOS PARK IL, US
THOMAS GALLAGHER - Golden CO, US
CHARLES CANTRELL - CHICAGO IL, US

International Classification:

A61B 5/00
G01R 33/58
G01R 33/56
G06F 19/24
G16H 30/40

Abstract:

Systems and methods for converting grayscale values in magnetic resonance images having different image contrasts into normalized estimations of physiological quantities are provided. These methods provide consistency of data from scan-to-scan, which allows the data to be used for high-fidelity radiogenomic analyses. Imaging-derived radiogenomic heat maps, based on trained models of quantitative radiogenomic associations, can be generated from, the normalized images and can provide a novel technique to survey the often varied genetic landscape within a tumor.