Ting Zhang

US Patent:

20190233406, Aug 1, 2019

Filed:

Jan 11, 2019

Appl. No.:

16/246068

Inventors:

- Rahway NJ, US
James Mulhearn - Elkins Park PA, US
Junying Zheng - New Providence NJ, US
Ronald M. Kim - Summit NJ, US
Ting Zhang - Princeton Junction NJ, US
Anthony J. Roecker - Harleysville PA, US
Walter Won - Alpine NJ, US
Philippe Nantermet - Lansdale PA, US
Rajan Anand - Fanwood NJ, US
Gang Zhou - Bridgewater NJ, US
Deping Wang - Furlong PA, US
Liangqin Guo - Edison NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 417/12
A61K 31/426
A61K 31/433
A61K 31/427
A61K 31/551
C07D 277/52
C07D 285/08
A61K 45/06

Abstract:

Disclosed are compounds of Formula A, or a salt thereof:wherein R, R, and E are defined herein, which compounds have properties for inhibiting Na1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain disorders, cough, and itch using the same.

US Patent:

20190092738, Mar 28, 2019

Filed:

Mar 17, 2017

Appl. No.:

16/086654

Inventors:

- Kenilworth NJ, US
Mark E. Layton - Harleysville PA, US
Thomas J. Greshock - Collegeville PA, US
Joseph E. Pero - Harleysville PA, US
Ting Zhang - Princeton Junction NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Kenilworth NJ

International Classification:

C07D 277/52
C07D 285/08
A61K 31/635
A61K 45/06

Abstract:

Disclosed are compounds of Formula A-1, or a salt thereof: Formula A-1, where J, K, Q and R1 are as defined herein, which compounds have properties for inhibiting sodium ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-1 or their salts, and methods of treating pain (e.g. chronic pain), or cough or itch disorders using the same.

US Patent:

20180362518, Dec 20, 2018

Filed:

Dec 15, 2016

Appl. No.:

16/061815

Inventors:

Thomas J. GRESHOCK - West Point PA, US
James MULHEARN - West Point PA, US
Liangqin GUO - Kenilworth NJ, US
Ting ZHANG - Rahway NJ, US
Deping WANG - West Point PA, US
Ronald M. KIM - Kenilworth NJ, US
Mark E. LAYTON - West Point PA, US
Rajan ANAND - Kenilworth NJ, US
Tianying JIAN - Rahway NJ, US
Philippe NANTERMET - West Point PA, US
Anthony J. ROECKER - West Point PA, US
Walter WON - Alpine NJ, US
Gang ZHOU - Bridgewater NJ, US
- Rahway NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 417/12
C07D 285/135
C07D 277/52
A61P 11/14
A61P 17/04
A61P 25/04
A61P 25/02

Abstract:

Disclosed are compounds of Formula A, or a salt thereof, where Q, X, R1 and R2 are as defined herein, which compounds have properties for inhibiting Na 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain (acute, post-operative, neuropathic), or cough or itch disorders using the same.

US Patent:

20170174674, Jun 22, 2017

Filed:

Dec 14, 2016

Appl. No.:

15/378465

Inventors:

- Rahway NJ, US
James Mulhearn - Elkins Park PA, US
Junying Zheng - New Providence NJ, US
Ronald M. Kim - Summit NJ, US
Ting Zhang - Princeton Junction NJ, US
Anthony J. Roecker - Harleysville PA, US
Walter Won - Alpine NJ, US
Philippe Nantermet - Lansdale PA, US
Rajan Anand - Fanwood NJ, US
Gang Zhou - Bridgewater NJ, US
Deping Wang - Furlong PA, US
Liangqin Guo - Edison NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 417/12
C07D 277/52
A61K 31/551
A61K 31/427
A61K 31/433
A61K 31/426
C07D 285/08
A61K 45/06

Abstract:

Disclosed are compounds of Formula A, or a salt thereof:wherein R, R, and E are defined herein, which compounds have properties for inhibiting Na1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain disorders, cough, and itch using the same.