Wing C Cheung

US Patent:

6696056, Feb 24, 2004

Filed:

Apr 7, 2000

Appl. No.:

09/545479

Inventors:

Wing K. Cheung - Warren NJ
Jaya Natarajan - Hillsborough NJ
Marilyn Sanders - Raritan NJ
Els Vercammen - Dietlikon, CH
Selima Begum - Edison NJ
Basant Sharma - Bridgewater NJ

Assignee:

Ortho McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 3819

US Classification:

424 851, 514 8, 514 21

Abstract:

The present invention provides aqueous pharmaceutical formulations of erythropoietin that are free of human serum blood products, stabilized with a quantity of an amino acid and a sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl) derivative. The present invention also provides aqueous stable, preserved pharmaceutical formulations of erythropoietin that contain an antimicrobial quantity of cresol and a quantity of an amino acid.

US Patent:

6747002, Jun 8, 2004

Filed:

May 10, 2000

Appl. No.:

09/569612

Inventors:

Wing Cheung - Warren NJ
David Gibson - Bassersdorf, CH
Christine Cote - Skillman NJ
Els Vercammen - Dietlikon, CH

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 3819

US Classification:

514 8, 530351

Abstract:

The present invention relates to systems and methods for obtaining optimized EPO dosage regimens for a desired pharmacodynamic/pharmacokinetic response. The system includes choosing one or more EPO dosage regimens, then using a PK/PD model to determine the pharmacodynamic/pharmacokinetic profile of one or more EPO dosage regimens, and finally selecting one of the EPO dosage regimens for administration to achieve the desired pharmacodynamic/pharmacodynamic response based on the EPO profile.

US Patent:

6818613, Nov 16, 2004

Filed:

Nov 7, 2001

Appl. No.:

10/037369

Inventors:

Basant Sharma - Bridgewater NJ
Renzhe Jin - Bridgewater NJ
Sunitha Rudolph - Doylestown PA
Wing K. Cheung - Warren NJ
Selima Begum - Edison NJ
Marian Kelley - Annandale NJ

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 3816

US Classification:

514 8

Abstract:

The present invention is directed to sustained-release pharmaceutical formulations of therapeutic proteins containing carboxymethyl ether cellulose polymer and methods of manufacture and use thereof.

US Patent:

7282480, Oct 16, 2007

Filed:

Aug 18, 2004

Appl. No.:

10/920803

Inventors:

Basant Sharma - Bridgewater NJ, US
Renzhe Jin - Bridgewater NJ, US
Sunitha Menon-Rudolph - Doylestown PA, US
Wing K. Cheung - Warren NJ, US
Selima Begum - Edison NJ, US
Marian Kelley - West Chester PA, US

Assignee:

Ortho-McNeil Pharmaceutical, Inc. - Raritan NJ

International Classification:

A61K 38/16

US Classification:

514 8

Abstract:

The present invention is directed to sustained-release pharmaceutical formulations of therapeutic proteins containing carboxymethyl ether cellulose polymer and methods of manufacture and use thereof.

US Patent:

7612211, Nov 3, 2009

Filed:

Dec 12, 2007

Appl. No.:

11/954647

Inventors:

Wing S. Cheung - Plainsboro NJ, US
Daniel J. Parks - Downingtown PA, US
William H. Parsons - Belle Mead NJ, US
Sharmila Patel - Jamison PA, US
Mark R. Player - Phoenixville PA, US

Assignee:

Janssen Pharmaceutica N.V. - Beerse

International Classification:

A61K 31/4184
C07D 235/12

US Classification:

5483101, 514394

Abstract:

The invention is directed to compounds of Formula (I):.

US Patent:

20030181361, Sep 25, 2003

Filed:

Mar 31, 2003

Appl. No.:

10/403115

Inventors:

Basant Sharma - Bridgewater NJ, US
Renzhe Jin - Bridgewater NJ, US
Sunitha Rudolph - Doylestown PA, US
Wing Cheung - Warren NJ, US
Selima Begum - Edison NJ, US
Marian Kelley - Annandale NJ, US

International Classification:

A61K038/22

US Classification:

514/008000, 514/012000

Abstract:

The present invention is directed to sustained-release pharmaceutical formulations of therapeutic proteins containing carboxymethyl ether cellulose polymer and methods of manufacture and use thereof.

US Patent:

20040157778, Aug 12, 2004

Filed:

Mar 24, 2004

Appl. No.:

10/807429

Inventors:

Wing Cheung - Warren NJ, US
David Gibson - Basserdorf, CH
Christine Cote - Skillman NJ, US
Els Vercammen - Dietlikon, CH

International Classification:

A61K038/18

US Classification:

514/012000

Abstract:

The present invention relates to systems and methods for obtaining optimized EPO dosage regimens for a desired pharmacodynamic/pharmacokinetic response. The system includes choosing one or more EPO dosage regimens, then using a PK/PD model to determine the pharmacodynamic/pharmacokinetic profile of one or more EPO dosage regimens, and finally selecting one of the EPO dosage regimens for administration to achieve the desired pharmacodynamic/pharmacodynamic response based on the EPO profile.

US Patent:

20040176297, Sep 9, 2004

Filed:

Mar 24, 2004

Appl. No.:

10/807451

Inventors:

Wing Cheung - Warren NJ, US
David Gibson - Bassersdorf, CH
Christine Cote - Skillman NJ, US
Els Vercammen - Dietlikon, CH

International Classification:

A61K038/18
G01N033/48
G01N033/50
A61K033/24

US Classification:

514/012000, 424/649000, 702/019000

Abstract:

The present invention relates to systems and methods for obtaining optimized EPO dosage regimens for a desired pharmacodynamic/pharmacokinetic response. The system includes choosing one or more EPO dosage regimens, then using a PK/PD model to determine the pharmacodynamic/pharmacokinetic profile of one or more EPO dosage regimens, and finally selecting one of the EPO dosage regimens for administration to achieve the desired pharmacodynamic/pharmacodynamic response based on the EPO profile.