Xiaodong Wu

US Patent:

58887636, Mar 30, 1999

Filed:

Dec 30, 1994

Appl. No.:

8/367070

Inventors:

Beatrice S. Knudsen - New York NY
Stephan M. Feller - New York NY
John Kuriyan - New York NY
Xiaodong Wu - New York NY
Jie Zheng - New York NY
David Cowburn - Westfield NJ

Assignee:

The Rockefeller University - New York NY

International Classification:

C12P 2106
C12N 120
C07H 2100

US Classification:

435 691

Abstract:

The present invention relates to regulation and control of cellular processes by SH3-domain binding proteins and peptides. In particular, the invention provides a consensus sequence of a peptide that shows high specificity and affinity for the first SH3 domain of cellular Crk. In specific examples, a number of peptides that contain the consensus are shown to bind c-Crk specifically. The molecular basis for this specificity is examined by crystallography.