Xuan Wang

US Patent:

20140024086, Jan 23, 2014

Filed:

Mar 29, 2012

Appl. No.:

14/008015

Inventors:

Elliot N. Miller - Indianapolis IN, US
Xueli Zhang - Tianjin, CN
Lorraine P. Yomano - Gainesville FL, US
Xuan Wang - Gainesville FL, US
Keelnatham T. Shanmugam - Gainesville FL, US
Lonnie O'Neal Ingram - Gainesville FL, US

Assignee:

UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. - GAINESVILLE FL

International Classification:

C12P 7/56
C12P 7/06
C12P 7/46

US Classification:

435106, 435136, 435139, 435140, 435145, 435158, 435160, 435161, 435476, 4352523, 43525231, 43525233, 43525411, 4352542, 43525421, 43525422, 43525423, 4352543, 4352544, 4352545, 4352546, 4352547, 4352548

Abstract:

The subject invention pertains to the discovery that the NADH-dependent propanediol oxidoreductase (FucO) can reduce furfural. This allows for a new approach to improve furfural tolerance in bacterial and/or yeast cells used to produce desired products. Thus, novel biocatalysts (bacterial, fungal or yeast cells) exhibiting increased tolerance to furfural and 5-hydroxymethylfurfural (5-HMF) are provided as are methods of making and using such biocatalysts for the production of a desired product.