Xuejun Wang

US Patent:

20200196925, Jun 25, 2020

Filed:

Mar 5, 2020

Appl. No.:

16/810183

Inventors:

- New York NY, US
- Iowa City IA, US
Junyi Shang - New York NY, US
Zhixing Zhang - New York NY, US
Xuejun Wang - New York NY, US
Jaeyoung Yang - New York NY, US
Cheng Wang - New York NY, US
Pavana G. Rotti - Iowa City IA, US
John F. Engelhardt - Iowa City IA, US
Zhuang Hao - New York NY, US

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY
DEPARTMENT OF ANATOMY AND CELL BIOLOGY - UNIVERSITY OF IOWA - Iowa City IA

International Classification:

A61B 5/145
G01N 33/74
G01N 27/414
H01L 21/02
H01L 29/16
H01L 23/38
A61B 5/1491
A61B 5/1477
A61B 5/00
H01L 51/05

Abstract:

A microdevice for monitoring a target analyte is provided. The microdevice can include a field effect transistor comprising a substrate, a gate electrode, and a microfluidic channel including graphene. The microfluidic channel can be formed between drain electrodes and source electrodes on the substrate. The microdevice can also include at least one aptamer functionalized on a surface of the graphene. The at least one aptamer can be adapted for binding to the target analyte. Binding of the target analyte to the at least one aptamer can alter the conductance of the graphene.

US Patent:

20180368743, Dec 27, 2018

Filed:

Jun 19, 2018

Appl. No.:

16/012527

Inventors:

- New York NY, US
- Iowa City IA, US
Junyi Shang - New York NY, US
Zhixing Zhang - New York NY, US
Xuejun Wang - New York NY, US
Jaeyoung Yang - New York NY, US
Cheng Wang - New York NY, US
Pavana G. Rotti - Iowa City IA, US
John F. Engelhardt - Iowa City IA, US
Zhuang Hao - New York NY, US

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW NEW YORK - New York NY
Department of Anatomy and Cell Biology - Universit y of Iowa - Iowa City IA

International Classification:

A61B 5/145
G01N 33/74
H01L 51/00
A61B 5/1477
A61B 5/1491
H01L 23/38
H01L 29/16
H01L 21/02
G01N 27/414

Abstract:

A microdevice for monitoring a target analyte is provided. The microdevice can include a field effect transistor comprising a substrate, a gate electrode, and a microfluidic channel including graphene. The microfluidic channel can be formed between drain electrodes and source electrodes on the substrate. The microdevice can also include at least one aptamer functionalized on a surface of the graphene. The at least one aptamer can be adapted for binding to the target analyte. Binding of the target analyte to the at least one aptamer can alter the conductance of the graphene.

US Patent:

20170350882, Dec 7, 2017

Filed:

Aug 21, 2017

Appl. No.:

15/682191

Inventors:

- New York NY, US
Yibo Zhu - New York NY, US
Junyi Shang - New York NY, US
Zhixing Zhang - New York NY, US
Xuejun Wang - New York NY, US
Jaeyoung Yang - New York NY, US
Cheng Wang - New York NY, US

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY

International Classification:

G01N 33/543
G01N 27/414
B01L 3/00
G01N 33/53

Abstract:

A microdevice for monitoring a target analyte is provided. The microdevice can include a field effect transistor comprising a substrate, a gate electrode, and a microfluidic channel including graphene. The microfluidic channel can be formed between drain electrodes and source electrodes on the substrate. The microdevice can also include at least one aptamer functionalized on a surface of the graphene. The at least one aptamer can be adapted for binding to the target analyte. Binding of the target analyte to the at least one aptamer can alter the conductance of the graphene.

US Patent:

20170181669, Jun 29, 2017

Filed:

Dec 9, 2016

Appl. No.:

15/374375

Inventors:

- New York NY, US
Yibo Zhu - New York NY, US
Junyi Shang - New York NY, US
Zhixing Zhang - New York NY, US
Xuejun Wang - New York NY, US
Jaeyoung Yang - New York NY, US
Cheng Wang - New York NY, US

International Classification:

A61B 5/145
G01N 33/66
G01N 33/543

Abstract:

A receptor capable of binding to the target analyte can be used in monitoring a target analyte in a bodily fluid or a sample. A microdevice in accordance with the disclosed subject matter can include a substrate and a conductance elements with receptors grafted on the surface of the conductance element. A microdevice in accordance with the disclosed subject matter can also include a substrate, a first and second conductance elements, and synthetic polymers grafted on the surface of the first and second conductance elements. The first conductance element can be grafted with a sensing polymer that binds the target analyte, and the second conductance element can be grafted with a reference polymer that is insensitive to the target analyte. Differential measurement of the graphene conductance can allow determination of target analyte concentration in a bodily fluid.