Young Hwa Chang

US Patent:

8574635, Nov 5, 2013

Filed:

Feb 16, 2011

Appl. No.:

12/932018

Inventors:

Sylvia Lee-Huang - New York NY, US
Paul L. Huang - Boston MA, US
Philip Lin Huang - Maple Glen PA, US
Dawei Zhang - Elmhurst NY, US
John Z. H. Zhang - New York NY, US
Young Tae Chang - New York NY, US
Jae Wook Lee - San Diego CA, US
Ju Bao - Brooklyn NY, US
Yongtao Sun - Xi'an, CN

Assignee:

New York University - New York NY
The General Hospital Corporation - Boston MA

International Classification:

A01N 65/00

US Classification:

424725

Abstract:

The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPARγ2, LPL and αP2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues.

US Patent:

20090061031, Mar 5, 2009

Filed:

Jul 9, 2007

Appl. No.:

11/827135

Inventors:

Sylvia Lee-Huang - New York NY, US
Paul L. Huang - Boston MA, US
Philip Lin Huang - Maple Glen PA, US
Dawei Zhang - Elmhurst NY, US
John Z.H. Zhang - New York NY, US
Young Tae Chang - New York NY, US
Jae Wook Lee - San Diego CA, US
Ju Bao - Brooklyn NY, US
Yongtao Sun - Chaanxi Province, CN

International Classification:

A61K 36/00
A61K 31/351
A61K 31/70
A61K 38/28
A61K 31/4439
A61K 31/435
A61K 31/366
A61K 31/7036
A61P 3/00
A61P 31/12
A61K 31/175
A61K 31/445
A61K 31/404
A61K 31/40
A61K 31/427
A61K 31/155
A61K 31/05

US Classification:

424774, 514460, 514734, 514 27, 514636, 514 4, 514369, 514342, 514423, 514277, 514419, 514635, 514634, 514331, 514 42, 514592

Abstract:

The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPARγ2, LPL and αP2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues.

US Patent:

20140296141, Oct 2, 2014

Filed:

Oct 1, 2013

Appl. No.:

14/042800

Inventors:

- Boston MA, US
- New York NY, US
Dawei Zhang - Elmhurst NY, US
John Z. H. Zhang - New York NY, US
Young Tae Chang - New York NY, US
Jae Wook Lee - San Diego CA, US
Ju Bao - Brooklyn NY, US
Yongtao Sun - Xi'an, CN
Paul L. Huang - Boston MA, US

Assignee:

The General Hospital Corporation - Boston MA
New York Univeristy - New York NY

International Classification:

A61K 31/7048
A61K 45/06
A61K 31/05

US Classification:

514 65, 514 27

Abstract:

The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPARγ2, LPL and αP2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues.