Wei-min Liu - Dublin CA, US Yan Li - Palo Alto CA, US Chih-Jian Lih - Gaithersburg MD, US Yu Chuan Tai - Pleasanton CA, US
Assignee:
Roche Molecular Systems, Inc. - Pleasanton CA
International Classification:
C12Q 1/68
US Classification:
435 611, 435 61
Abstract:
This invention provides methods, compositions, and kits relating to biomarkers whose expression levels are correlated with diffuse large B-cell lymphoma (DLCBL) patients' response to treatment with a CD20 antagonist, such as a CD20 antibody, exemplified by rituximab. The methods, compositions, and kits of the invention can be used to identify DLBCL patients who are likely or not likely, to respond to anti-CD20 treatments.
Richard S. Muller - Kensington CA Longsheng Fan - Berkeley CA Yu C. Tai - Albany CA
Assignee:
The Regents of the University of California - Berkeley CA
International Classification:
H02N 100
US Classification:
310309
Abstract:
A method for making and the product resulting from the method for making a microminiature electrical motor having a rotor rotatable about a fixed hub member within a surrounding stator, the diameter of the stator being typically in the range of 60-140 microns. Both synchronous and stepper motor configurations are described, each with structural features that provide increased performance and minimal rotor friction. The processes disclosed for making the micro-motors include the steps of: providing a substrate material with a first layer of silicon dioxide covered by an overlayer of silicon nitride; providing a first layer of sacrificial material on said substrate; providing a first structural layer over said sacrificial material; providing patterning and then etching said first structural layer to form said rotor and stator components; providing a second layer of sacrificial material over said first structural layer and patterning it to form an anchor opening in said substrate at the center of the rotor; providing a second structural layer to form a hub member in said anchor opening and patterning said second structural layer to form a flange for said hub member; and etching said sacrificial layers to separate said rotor and stator components and said rotor from said hub member so that it rotates about it. The invention also includes an ancillary method for protecting metallized elements in the motor circuit during the required etching steps for removal of sacrificial layers.
Micromechanical Elements And Methods For Their Fabrication
Richard S. Muller - Kensington CA Longsheng Fan - Berkeley CA Yu C. Tai - Albany CA
Assignee:
The Regents of the University of California - Berkeley CA
International Classification:
H01L 21306 B44C 122 C03C 1500 C23F 102
US Classification:
428133
Abstract:
A method and the product resulting from the method, for making a microminiature structure with two or more members measuring less than 1000 micrometers in any linear dimension and relatively movable to each other, comprising the steps of (a) providing a first sacrificial coating over a substrate having openings therethrough to expose a portion of the substrate, (b) depositing a first structural layer over the first sacrificial coating and the exposed portion of the substrate, with openings therethrough to expose a second portion of the substrate, (c) providing a second sacrificial coating over the second exposed portion of the substrate and said first structural layer, with openings through both the first and second sacrificial layers to expose a third portion of the substrate, (d) adding a second structural layer thereover and defining it, (e) possibly adding alternately other sacrificial coatings and other structural layers, and (f) etching the first and second and other sacrificial layers to remove them completely so that the two or more structural layers become movable relative to each other.
- Pleasanton CA, US Marcel Fontecha - San Ramon CA, US Yan Li - Palo Alto CA, US Wei-min Liu - Dublin CA, US Christopher Santini - Pleasant Hill CA, US Lori Steiner - Alameda CA, US Yu Chuan Tai - Pleasanton CA, US
International Classification:
C12Q 1/6886
Abstract:
Provided herein are methods and compositions to classify DLBCL subtypes using quantitative RT-PCR.
- Pleasanton CA, US Marcel Fontecha - San Ramon CA, US Yan Li - Palo Alto CA, US Wei-min Liu - Dublin CA, US Christopher Santini - Pleasant Hill CA, US Lori Steiner - Alameda CA, US Yu Chuan Tai - Pleasanton CA, US
International Classification:
C12Q 1/68
Abstract:
Provided herein are methods and compositions to classify DLBCL subtypes using quantitative RT-PCR.