Yu Qin Zheng

US Patent:

20180215828, Aug 2, 2018

Filed:

Mar 27, 2018

Appl. No.:

15/937809

Inventors:

- Stockton CA, US
Jerry TSAI - Stockton CA, US
Bhaskara Rao JASTI - Stockton CA, US
Hyun JOO - Stockton CA, US
Yu ZHENG - Stockton CA, US
Dan SU - Fremont CA, US
Sameer SACHDEVA - Piscataway NJ, US

International Classification:

C07K 16/28
C07K 7/08

Abstract:

The present disclosure relates to compositions and methods comprising peptide molecules that mimic the binding and functional properties of native antibodies relative to their respective targets. Some embodiments comprise peptide-drug conjugates (PDCs) comprising the mimic peptides disclosed herein. The targets of these mimic peptides include epidermal growth factor receptor (EGFR), and human epidermal growth factor receptor 2 (HER2), vascular endothelial growth factor (VEGF), programmed cell death protein 1 (PD-1), and programmed death-ligand 1 (PD-L1). The present disclosure comprises application of the knob-socket computational model to design antibody mimics for proteins.

US Patent:

20170101474, Apr 13, 2017

Filed:

Oct 13, 2015

Appl. No.:

14/882436

Inventors:

- Stockton CA, US
Jerry TSAI - Stockton CA, US
Bhaskara Rao JASTI - Stockton CA, US
Hyun JOO - Stockton CA, US
Yu ZHENG - Stockton CA, US
Dan SU - Fremont CA, US
Sameer SACHDEVA - Piscataway NJ, US

International Classification:

C07K 16/28
G01N 33/74

Abstract:

The present disclosure relates to compositions and methods comprising peptide molecules that mimic the binding and functional properties of native antibodies relative to their respective targets. Some embodiments comprise peptide-drug conjugates (PDCs) comprising the mimic peptides disclosed herein. The targets of these mimic peptides include epidermal growth factor receptor (EGFR), and human epidermal growth factor receptor 2 (HER2), vascular endothelial growth factor (VEGF), programmed cell death protein 1 (PD-1), and programmed death-ligand 1 (PD-L1). The present disclosure comprises application of the knob-socket computational model to design antibody mimics for proteins.