Yuan Cheng

US Patent:

7125865, Oct 24, 2006

Filed:

Jul 21, 2003

Appl. No.:

10/522114

Inventors:

A. Brian Jones - Walden, GB
Alan D. Adams - Cranford NJ, US
Ahren I. Green - Green Brook NJ, US
Shaei Y. Huang - Jeffersonville PA, US
Bruno Tse - Philadelphia PA, US
Clare E. Gutteridge - Annapolis MD, US
Yuan Cheng - Newbury Park CA, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D 277/04
C07D 277/12
C07D 261/20
C07D 421/00
C07D 241/00

US Classification:

51421208, 5142308, 514241, 51425402, 51425505, 514256, 514269, 514274, 514338, 514369, 514379, 540524, 544137, 544220, 544310, 544331, 544368, 544405, 5462721, 548183, 548241

Abstract:

The present invention relates to novel LXR ligands of Formula I and the pharmaceutically acceptable salts, esters and tautomers thereof, which are useful in the treatment of dyslipidemic conditions, particularly depressed levels of HDL cholesterol.

US Patent:

7435823, Oct 14, 2008

Filed:

Jan 24, 2005

Appl. No.:

11/042634

Inventors:

Michele Potashman - Cambridge MA, US
Steven Bellon - Wellesley MA, US
Shon Booker - Thousand Oaks CA, US
Yuan Cheng - Newbury Park CA, US
Joseph L. Kim - Wayland MA, US
Andrew Tasker - Simi Valley CA, US
Ning Xi - Thousand Oaks CA, US
Shimin Xu - Ventura CA, US
Jean-Christophe Harmange - Andover MA, US
George Borg - Cambridge MA, US
Matthew Weiss - Boston MA, US
Brian L. Hodous - Cambridge MA, US
Russell Graceffa - Hampton NH, US
William H. Buckner - Arlington MA, US
Craig E. Masse - Cambridge MA, US
Deborah Choquette - Medford MA, US
Matthew W. Martin - Cambridge MA, US
Julie Germain - Medford MA, US
Lucian V. DiPietro - Gloucester MA, US
Stuart C. Chaffee - Cambridge MA, US
Joseph J. Nunes - Andover MA, US
John L. Buchanan - Brookline MA, US
Gregory J. Habgood - Merrimac MA, US
David C. McGowan - Woluwe St. Pierre, BE
Douglas A. Whittington - Waltham MA, US
Daniel La - Brookline MA, US
Vinod F. Patel - Acton MA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 215/38
C07D 265/34

US Classification:

546153, 546 15, 544 99, 544105

Abstract:

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

US Patent:

7626030, Dec 1, 2009

Filed:

Jan 24, 2005

Appl. No.:

11/042398

Inventors:

Jean-Christophe Harmange - Andover MA, US
David Bauer - Sudbury MA, US
Shon Booker - Thousand Oaks CA, US
Yuan Cheng - Newbury Park CA, US
Shimin Xu - Santa Barbara CA, US
Ning Xi - Thousand Oaks CA, US
Joseph L. Kim - Wayland MA, US
Andrew Tasker - Simi Valley CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 215/38

US Classification:

546157, 546153

Abstract:

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

US Patent:

7652009, Jan 26, 2010

Filed:

Nov 29, 2005

Appl. No.:

11/289659

Inventors:

Steven Bellon - Wellesley MA, US
Shon Booker - Thousand Oaks CA, US
Noel D'Angelo - Thousand Oaks CA, US
Celia Dominguez - Los Angeles CA, US
Ingrid Fellows - Fresno CA, US
Matthew Lee - Calabasas CA, US
Longbin Liu - Thousand Oaks CA, US
Elizabeth Rainbeau - Port Hueneme CA, US
Aaron C. Siegmund - Ventura CA, US
Andrew Tasker - Simi Valley CA, US
Ning Xi - Thousand Oaks CA, US
Yuan Cheng - Newbury Park CA, US

Assignee:

Amgem Inc. - Thousand Oaks CA

International Classification:

A61K 31/506
C07D 401/02
C07D 239/22

US Classification:

51425204, 514269, 544238, 544242, 544298, 544319

Abstract:

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

US Patent:

7745484, Jun 29, 2010

Filed:

Nov 10, 2006

Appl. No.:

11/595187

Inventors:

Wenge Zhong - Thousand Oaks CA, US
Stephen Hitchcock - Westlake Village CA, US
Brian K. Albrecht - Cambridge MA, US
Michael D. Bartberger - Sherman Oaks CA, US
James Brown - Moorpark CA, US
Ryan Brown - Watertown MA, US
Stuart C. Chaffee - Philadelphia PA, US
Yuan Cheng - Newbury Park CA, US
Michael Croghan - Thousand Oaks CA, US
Russell Graceffa - Hampton NH, US
Scott Harried - Woodland Hills CA, US
Dean Hickman - Moorpark CA, US
Dan Horne - Thousand Oaks CA, US
Randall Hungate - San Francisco CA, US
Ted Judd - Simi Valley CA, US
Matthew Kaller - Ventura CA, US
Charles Kreiman - Watertown MA, US
Daniel La - Brookline MA, US
Patricia Lopez - West Hills CA, US
Craig Masse - Cambridge MA, US
Holger Monenschein - Camarillo CA, US
Thomas Nguyen - Thousand Oaks CA, US
Thomas Nixey - Newbury Park CA, US
Vinod F. Patel - Acton MA, US
Lewis Pennington - Ventura CA, US
Matthew Weiss - Boston MA, US
Qiufen Xue - Newbury Park CA, US
Bryant Yang - Simi Valley CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 31/352
C07D 311/96

US Classification:

514454, 549331

Abstract:

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I.

US Patent:

7838676, Nov 23, 2010

Filed:

Nov 14, 2006

Appl. No.:

11/599901

Inventors:

Qiufen Xue - Newbury Park CA, US
Brian K. Albrecht - Cambridge MA, US
Denise Lyn Andersen - Simi Valley CA, US
Michael Bartberger - Sherman Oaks CA, US
James Brown - Moorpark CA, US
Ryan Brown - Belmont MA, US
Stuart C. Chaffee - Philadelphia PA, US
Yuan Cheng - Newbury Park CA, US
Michael Croghan - Thousand Oaks CA, US
Russell Graceffa - Hampton NH, US
Scott Harried - Woodland Hills CA, US
Stephen Hitchcock - Westlake Village CA, US
Randall Hungate - Camarillo CA, US
Ted Judd - Simi Valley CA, US
Matthew Kaller - Ventura CA, US
Charles Kreiman - Watertown MA, US
Daniel La - Brookline MA, US
Patricia Lopez - West Hills CA, US
Craig Masse - Cambridge MA, US
Holger Monenschein - Camarillo CA, US
Thomas Nguyen - Thousand Oaks CA, US
Thomas Nixey - Newbury Park CA, US
Vinod F. Patel - Acton MA, US
Lewis Pennington - Camarillo CA, US
Matthew Weiss - Boston MA, US
Bryant Yang - Simi Valley CA, US
Wenge Zhong - Thousand Oaks CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 498/02
C07D 401/00

US Classification:

546 18, 546115

Abstract:

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I.

US Patent:

7872009, Jan 18, 2011

Filed:

Nov 14, 2006

Appl. No.:

11/600264

Inventors:

Brian K. Albrecht - Cambridge MA, US
Denise Lyn Andersen - Simi Valley CA, US
Michael Bartberger - Sherman Oaks CA, US
James Brown - Moorpark CA, US
Ryan Brown - Belmont MA, US
Stuart C. Chaffee - Philadelphia PA, US
Yuan Cheng - Newbury Park CA, US
Michael Croghan - Thousand Oaks CA, US
Russell Graceffa - Hampton NH, US
Scott Harried - Woodland Hills CA, US
Stephen Hitchcock - Westlake Village CA, US
Randall Hungate - Camarillo CA, US
Ted Judd - Simi Valley CA, US
Matthew Kaller - Ventura CA, US
Charles Kreiman - Watertown MA, US
Daniel La - Brookline MA, US
Patricia Lopez - West Hills CA, US
Craig Masse - Cambridge MA, US
Holger Monenschein - Camarillo CA, US
Thomas Nguyen - Thousand Oaks CA, US
Thomas Nixey - Newbury Park CA, US
Vinod F. Patel - Acton MA, US
Lewis Pennington - Camarillo CA, US
Matthew Weiss - Boston MA, US
Qiufen Xue - Newbury Park CA, US
Bryant Yang - Simi Valley CA, US
Wenge Zhong - Thousand Oaks CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 31/50

US Classification:

51425201, 544238, 544298, 544408, 546242, 549398

Abstract:

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I.

US Patent:

7880000, Feb 1, 2011

Filed:

May 9, 2005

Appl. No.:

11/126000

Inventors:

Stephanie D. Geuns-Meyer - Medford MA, US
Brian L. Hodous - Cambridge MA, US
Stuart C. Chaffee - Cambridge MA, US
Paul A. Tempest - Brookline MA, US
Philip R. Olivieri - Medford MA, US
Rebecca E. Johnson - Arlington VA, US
Brian K. Albrecht - Cambridge MA, US
Vinod F. Patel - Acton MA, US
Victor J. Cee - Mansfield MA, US
Joseph L. Kim - Wayland MA, US
Steven Bellon - Wellesley MA, US
Xiaotian Zhu - Newton MA, US
Yuan Cheng - Newbury Park CA, US
Ning Xi - Thousand Oaks CA, US
Karina Romero - Cambridge MA, US
Hanh Nho Nguyen - Arlington MA, US
Holly L. Deak - Brookline MA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 401/14
C07D 403/14
A61K 31/53
A61K 31/4427
A61K 31/506
A61P 19/02
A61P 35/00

US Classification:

544320, 544322, 544182, 514272, 514274, 514242

Abstract:

The present invention relates to chemical compounds having a general formula I.