Yucheng O Zhang from Whitestown, IN, age 39

Methods For Thaxtomin Production And Engineered Non-Native Streptomyces With Increased Thaxtomin Production
view source
US Patent:

20200140905, May 7, 2020
Filed:

May 23, 2018
Appl. No.:

16/616059
Inventors:

- Gainesville FL, US
Yucheng ZHANG - Gainesville FL, US
Yousong DING - Gainesville FL, US
Guangde JIANG - Gainesville FL, US
International Classification:

C12P 17/16
C12N 1/20
Abstract:

The present disclosure includes genetically engineered, non-pathogenic bacterium with exogenous, non-native Thaxtomin A (ThxA) biosynthetic gene clusters conferring the genetically engineered, non-pathogenic bacterium with the ability to produce thaxtomin A. Also included are methods of providing thaxtomin producing capability in non-native bacterial strains, methods of producing thaxtomin compounds with the genetically engineered bacteria of the present disclosure, and methods of producing thaxtomin compounds and nitro-tryptophan analogs, and fluorinated thaxtomin compounds, analogs, and intermediates with the genetically engineered bacteria of the present disclosure.