- Gainesville FL, US Yucheng ZHANG - Gainesville FL, US Yousong DING - Gainesville FL, US Guangde JIANG - Gainesville FL, US
International Classification:
C12P 17/16 C12N 1/20
Abstract:
The present disclosure includes genetically engineered, non-pathogenic bacterium with exogenous, non-native Thaxtomin A (ThxA) biosynthetic gene clusters conferring the genetically engineered, non-pathogenic bacterium with the ability to produce thaxtomin A. Also included are methods of providing thaxtomin producing capability in non-native bacterial strains, methods of producing thaxtomin compounds with the genetically engineered bacteria of the present disclosure, and methods of producing thaxtomin compounds and nitro-tryptophan analogs, and fluorinated thaxtomin compounds, analogs, and intermediates with the genetically engineered bacteria of the present disclosure.