Abigail J Shepard

US Patent:

20200009274, Jan 9, 2020

Filed:

Mar 13, 2018

Appl. No.:

16/493668

Inventors:

- Tucson AZ, US
Iman Daryaei - Tucson AZ, US
Abigail Shepard - Tucson AZ, US

International Classification:

A61K 51/04

Abstract:

A method for preparing F radiolabeled biomolecules and agents for F-PET imaging is disclosed herein. A perfluoroaryl-conjugated target tracer is synthesized and purified with temperature and solvent conditions that are mild for the tracer molecule. The purified perfluoroaryl-conjugated target tracer is then labeled with F using F salts within a short reaction time, and with temperature and solvent conditions that are mild for the tracer molecule. The method provides a quick and convenient process that maintains the biological activities of the target molecules. The radio-labeled biomolecules may be used as contrast agents for Positron Emission Tomography (PET).