Ai Li Lin from Rockville, MD, age 55

Antivesicant Compounds And Methods Of Making And Using Thereof
view source
US Patent:

6664280, Dec 16, 2003
Filed:

Jun 17, 2002
Appl. No.:

10/172074
Inventors:

Ai J. Lin - North Potomac MD
Michael C. Babin - Bel Air MD
Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:

A61K 3144
US Classification:

514358, 546347
Abstract:

As disclosed herein, the present invention provides a compound having the structural formula wherein R , R , R , and R are each independently H, or a methyl, halo, trifluoromethyl, nitro, alkyloxy, or acyloxy group, or a pharmaceutically acceptable salt or prodrug thereof. Also disclosed are compounds, compositions, methods and kits for treating, preventing, or inhibiting injuries induced by a vesicant agent, such as bis-2-chloroethylsulfide (HD). Additionally, protectants and decontaminants are disclosed.

Chemosensitizing Agents Against Chloroquine Resistant Plasmodium Falciparum And Methods Of Making And Using Thereof
view source
US Patent:

6800618, Oct 5, 2004
Filed:

May 7, 2001
Appl. No.:

09/849400
Inventors:

Ai J. Lin - Gaithersburg MD
Jian Guan - Silver Spring MD
Dennis E. Kyle - Gaithersburg MD
Wilbur K. Milhous - Germantown MD
Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:

A61K 3133
US Classification:

514183, 514299, 5142252, 514225, 514226, 544 14, 544 35, 544 41, 544 44, 548566, 548579, 546152, 546159
Abstract:

A compound having the structural formula or a pharmaceutically acceptable salt or prodrug thereof, wherein X is a substituted or unsubstituted alkyl or a heteroatom; n is 4, 5 or 6; Y is a substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or wherein R and R are each independently, H, a heteroatom, substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl; and wherein each ring structure are independently substituted or unsubstituted is disclosed. Also disclosed are chemosensitizing agents and methods of modulating, attenuating, reversing, or affecting a cells or organisms resistance to a given drug such as an antimalarial.

2-Guanidinylimidazolidinedione Compounds And Methods Of Making And Using Thereof
view source
US Patent:

7101902, Sep 5, 2006
Filed:

Nov 19, 2004
Appl. No.:

10/992363
Inventors:

Ai Jeng Lin - North Potomac MD, US
Quan Zhang - Montgomery County MD, US
Jian Guan - Montgomery County MD, US
Wilbur K. Milhous - Germantown MD, US
Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:

A61K 31/4168
C07D 233/48
US Classification:

514390, 5483181
Abstract:

Disclosed herein are 2-guanidinylimidazolidinedione compounds having the structural formula A or B.

Synthesis And Antimalarial Activity Of Pyrrolo[3,2-F]Quinazoline-1,3-Diamine Derivatives
view source
US Patent:

7253177, Aug 7, 2007
Filed:

Oct 22, 2004
Appl. No.:

10/971846
Inventors:

Ai J. Lin - Potomac MD, US
Jian Guan - Olney MD, US
Quan Zhang - Rockville MD, US
Donald R. Skillman - Silver Spring MD, US
Assignee:

United States of America as Represented by the Secretary of the Army - Washington DC
International Classification:

A01N 43/54
A61K 31/505
C07D 239/00
C07D 471/00
C07D 487/00
C07D 491/00
US Classification:

514267, 544247
Abstract:

The invention relates to derivatives of pyrroloquinazolinediamine, more specifically derivatives of 7-(substituted)-7H-pyrrolo[3,2-F] quinazoline-1,3-diamines that are non-toxic and are also effective in the treatment of malaria, including and strains. The derivatives are certain carbamate derivatives, succinimide derivatives, alkylcarboxamides derivatives and acetamide derivative, phthalimides, alkylamines and all other amide and imide derivatives and their 1-hydroxy analogs. The derivatives of the present invention are also soluble in common organic solvents to facilitate the purification in a large scale synthesis of the composition.

Imidazolidinedione Derivatives As Antimalarial Agents, Preparation Thereof, And Methods Of Use
view source
US Patent:

8283370, Oct 9, 2012
Filed:

Oct 2, 2009
Appl. No.:

13/122140
Inventors:

Ai Jeng Lin - North Potomac MD, US
Michael P. Kozar - Monrovia MD, US
Michael T. O'Neil - Jefferson MD, US
Alan J. Magill - Kensington MD, US
David L. Saunders - APO AP, US
Assignee:

The United States of America as Represented by the Secretary of the Army - Washington DC
International Classification:

A61K 31/4166
C07D 233/30
US Classification:

514390, 5483181
Abstract:

Embodiments disclosed herein relate to new imidazolidinedione derivatives, methods of making these compounds, and methods of using the same to prevent, treat, or inhibit malaria in a subject.

Intravenous Formulation Of Artelinic Acid For Treatment Of Severe And Complicated Malaria
view source
US Patent:

20030171424, Sep 11, 2003
Filed:

Feb 27, 2003
Appl. No.:

10/376420
Inventors:

Ai Lin - Gaithersburg MD, US
John VanHamont - Fort Meade MD, US
Wilbur Milhous - Germantown MD, US
International Classification:

A61K031/335
US Classification:

514/452000
Abstract:

Chemical entities of artelinic acid-L-lysine salts and their intravenous formulation for treatment of severe and complicated malaria, especially the cerebral malaria, which is fatal if not treated promptly, and method of making an intravenous artelinic acid-L-lysine salt formulation.

Novel Antimalarial Dihydroartemisinin Derivatives
view source
US Patent:

47911352, Dec 13, 1988
Filed:

Aug 20, 1987
Appl. No.:

7/087365
Inventors:

Ai J. Lin - Gaithersburg MD
Daniel L. Klayman - Chevy Chase MD
Wilbur K. Milhous - Rockville MD
Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC
International Classification:

C07D49318
A61K 31335
US Classification:

514450
Abstract:

This invention relates to novel dihydroartemisinin derivatives, including their pharmaceutically-acceptable salts, which are therapeutically-effective in the pre- and post-treatment of malarial infections.