Alan P Avakian

US Patent:

6440408, Aug 27, 2002

Filed:

Sep 26, 1997

Appl. No.:

08/938740

Inventors:

John A. Thoma - Fayetteville AR
Eid E. Haddad - Cary NC
Craig E. Whitfill - Apex NC
Alan P. Avakian - Raleigh NC

Assignee:

University of Arkansas - Fayetteville AR

International Classification:

A01N 6300

US Classification:

424 931, 424 9321, 424 934, 4241781, 4241801, 4241841, 4241931, 42419711

Abstract:

A method of producing active immunity against a bacterial or protozoal disease in a subject comprises administering to the subject a vaccine conjugate comprising a live bacteria or protozoa and a neutralizing factor bound to the live bacteria or protozoa. The neutralizing factor is selected from the group consisting of antibodies and antibody fragments. The live bacteria or protozoa is one capable of producing disease in the subject, and the antibody or antibody fragment is one capable of neutralizing the live bacteria or protozoa.

US Patent:

6890527, May 10, 2005

Filed:

May 24, 2002

Appl. No.:

10/154880

Inventors:

John A. Thoma - Fayetteville AR, US
Eid E. Haddad - Cary NC, US
Craig E. Whitfill - Apex NC, US
Alan P. Avakian - Raleigh NC, US

Assignee:

The University of Arkansas - Fayetteville AR

International Classification:

A01N063/00
A01N065/00
A61K039/00
A61K039/38
A61K039/385

US Classification:

424 931, 424 9321, 424 937, 4241841, 4241931, 4242651, 4242691, 4242711

Abstract:

A method of producing active immunity against a bacterial or protozoal disease in a subject comprises administering to the subject a vaccine conjugate comprising a live bacteria or protozoa and a neutralizing factor bound to the live bacteria or protozoa. The neutralizing factor is selected from the group consisting of antibodies and antibody fragments. The live bacteria or protozoa is one capable of producing disease in the subject, and the antibody or antibody fragment is one capable of neutralizing the live bacteria or protozoa.

US Patent:

20070243199, Oct 18, 2007

Filed:

Mar 29, 2007

Appl. No.:

11/729618

Inventors:

Vivian Doelling - Cary NC, US
Rebecca Poston - Raleigh NC, US
Cherilyn Heggen-Peay - Apex NC, US
Alan Avakian - Raleigh NC, US

International Classification:

A61K 39/00
A61K 39/295
A61K 39/12
A61K 39/02

US Classification:

424184100, 424204100, 424234100, 424201100

Abstract:

The present invention provides methods of inducing an immune response against species in birds, for protecting birds from infection, and/or for protecting birds from related disorders such as necrotic enteritis. The methods can be practiced in ovo and/or post-hatch. The invention further provides compositions and methods for delivery of a composition of this invention in ovo directly to the embryo body.

US Patent:

20070243212, Oct 18, 2007

Filed:

Mar 29, 2007

Appl. No.:

11/729678

Inventors:

Vivian Doelling - Cary NC, US
Rebecca Poston - Raleigh NC, US
Cherilyn Heggen-Peay - Apex NC, US
Alan Avakian - Raleigh NC, US

International Classification:

A61K 39/295
A61K 39/08

US Classification:

424201100, 424239100

Abstract:

The present invention provides methods of inducing an immune response against species in birds, for protecting birds from infection, and/or for protecting birds from related disorders such as necrotic enteritis. The methods can be practiced in ovo and/or post-hatch. The invention further provides compositions and methods for delivery of a composition of this invention in ovo directly to the embryo body.

US Patent:

20100136049, Jun 3, 2010

Filed:

Nov 24, 2009

Appl. No.:

12/624610

Inventors:

VIVIAN W. DOELLING - CARY NC, US
REBECCA M. POSTON - RALEIGH NC, US
CHERILYN L. HEGGEN-PEAY - APEX NC, US
ALAN P. AVAKIAN - RALEIGH NC, US

International Classification:

A61K 39/08
A61K 39/00
A61K 39/295
A61P 31/04
A61P 31/12

US Classification:

4242011, 4241841, 4242391

Abstract:

The present invention provides methods of inducing an immune response against species in birds, for protecting birds from infection, and/or for protecting birds from related disorders such as necrotic enteritis. The methods can be practiced in ovo and/or post-hatch. The invention further provides compositions and methods for delivery of a composition of this invention in ovo directly to the embryo body.

US Patent:

20100143403, Jun 10, 2010

Filed:

Nov 24, 2009

Appl. No.:

12/624601

Inventors:

Vivian W. Doelling - Cary NC, US
Rebecca M. Poston - Raleigh NC, US
Cherilyn L. Heggen-Peay - Apex NC, US
Alan P. Avakian - Raleigh NC, US

International Classification:

A61K 39/08
A61K 39/00
A61P 31/04
A61P 31/12
A61K 39/295

US Classification:

4242011, 4241841, 4242391

Abstract:

The present invention provides methods of inducing an immune response against species in birds, for protecting birds from infection, and/or for protecting birds from related disorders such as necrotic enteritis. The methods can be practiced in ovo and/or post-hatch. The invention further provides compositions and methods for delivery of a composition of this invention in ovo directly to the embryo body.

US Patent:

51965143, Mar 23, 1993

Filed:

Mar 6, 1990

Appl. No.:

7/489011

Inventors:

Alan P. Avakian - Raleigh NC
Stanley H. Kleven - Athens GA

Assignee:

The University of Georgia Research Foundation, Inc. - Athens GA

International Classification:

C12N 100
C12N 120
C07K 300
C07K 1300
C07K 1500
C07K 1700

US Classification:

530350

Abstract:

The present invention relates to the identification and purification of antigens from M. gallisepticum and M. synoviae and their use in serological assays. Cell proteins from these organisms that possess substantial immunoreactive responses with poultry antisera to the mycoplasma from which they are isolated in both the acute and convalescent stages of infection are identified. Of these immunogenic proteins, those that also lack immunogenic cross-reactivity with antisera to other poultry mycoplasmas and pathogens are identified. These species specific proteins are purified and incorporated into enzyme-linked immunosorbent assays (ELISAs). The resulting assays are able to detect sensitively and selectively both field or experimentally-induced M. gallisepticum or M. synoviae infection in poultry.