Amy L Strong

US Patent:

20160068542, Mar 10, 2016

Filed:

Apr 4, 2014

Appl. No.:

14/781494

Inventors:

- New Orleans LA, US
Amy STRONG - New Orleans LA, US
Stephen BOUE - New Orleans LA, US
Matthew BUROW - New Orleans LA, US
Bruce BUNNELL - New Orleans LA, US
Quan JIANG - New Orleans LA, US
Shilong ZHENG - New Orleans LA, US
Guangdi WANG - New Orleans LA, US

International Classification:

C07D 493/04
A61K 35/28
C07D 311/04
A61K 31/352

Abstract:

Disclosed are daidzein analogs having the formula (I). Also disclosed are compositions, include a disclosed daidzein analogs, methods of preventing or treating bone disease or bone injury and/or stimulating bone growth, in a subject that include administering to the subject an effective amount of disclosed daidzein analog. Disclosed are isolated mesenchymal stem cell that has been altered by treatment a disclosed daidzein analog, daidzein, glycinol, glyceollin I, or glyceollin II, to increase the osteogenic potential of the mesenchymal stem cells.