Brian K Chang

US Patent:

20220257921, Aug 18, 2022

Filed:

May 2, 2022

Appl. No.:

17/734819

Inventors:

- Danvers MA, US
- Cambridge MA, US
- Boston MA, US
Alexander Ship - Danvers MA, US
Sonya Sanat Bhavsar - Danvers MA, US
Noam Josephy - Danvers MA, US
Elazer R. Edelman - Cambridge MA, US
Brian Yale Chang - Cambridge MA, US
Steven Keller - Cambridge MA, US

Assignee:

ABIOMED, Inc. - Danvers MA
Massachusetts Institute of Technology - Cambridge MA
The Brigham and Women's Hospital, Inc. - Boston MA

International Classification:

A61M 60/50
G16H 50/50
G16H 40/63
A61B 5/021
A61B 5/0215
A61M 60/148

Abstract:

The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.

US Patent:

20200261635, Aug 20, 2020

Filed:

Sep 17, 2018

Appl. No.:

16/647942

Inventors:

Steven Paul KELLER - Brookline MA, US
Brian Yale CHANG - Boston MA, US
Jayon WANG - Allston MA, US

International Classification:

A61M 1/16
B01D 19/00

Abstract:

Systems, devices, and methods are provided for removing carbon dioxide from a target fluid, such as, for example, blood, to treat hypercarbic respiratory failure or another condition. A device is provided including first and second membrane components for removing dissolved gaseous carbon dioxide and bicarbonate from the fluid, which can be done simultaneously. The device can be in the form of a cartridge configured for use in a dialysis system. A method of treatment is also provided, involving drawing blood from a patient and bringing the patient's blood in contact with a first membrane component having a sweep gas passing therethrough, and a second membrane component having a dialysate passing therethrough. The dialysate's composition can be selected such that charge neutrality is maintained.

US Patent:

20200086022, Mar 19, 2020

Filed:

Jun 19, 2019

Appl. No.:

16/446419

Inventors:

- Danvers MA, US
- Cambridge MA, US
- Boston MA, US
Alexander Ship - Danvers MA, US
Sonya Sanat Bhavsar - Danvers MA, US
Noam Josephy - Danvers MA, US
Elazer R. Edelman - Cambridge MA, US
Brian Yale Chang - Cambridge MA, US
Steven Keller - Cambridge MA, US

International Classification:

A61M 1/10
A61M 1/12

Abstract:

The systems and methods described herein determine metrics of cardiac performance via a mechanical circulatory support device and use the cardiac performance to calibrate, control and deliver mechanical circulatory support for the heart. The systems include a controller configured to operate the device, receive inputs indicative of device operating conditions and hemodynamic parameters, and determine vascular performance, including vascular resistance and compliance, and native cardiac output. The systems and methods operate by using the mechanical circulatory support device (e.g., a heart pump) to introduce controlled perturbations of the vascular system and, in response, determine heart parameters such as stroke volume, vascular resistance and compliance, left ventricular end diastolic pressure, and ultimately determine native cardiac output.