- College Park MD, US CHAO LI - COLLEGE PARK MD, US SHILEI ZHU - HALETHORPE MD, US
Assignee:
UNIVERSITY OF MARYLAND, BALTIMORE COUNTY - BALTIMORE MD
International Classification:
C12P 21/00
Abstract:
The present invention provides for novel fucosidase mutants that server as fuco-ligases for core fucosylation of a range of biological glycopeptides and glycoproteins including intact therapeutic antibodies. Several mutants with mutation at the general acid/base residue E274 of the α1,6-fucosidase, including E274A, E274S, and E274G, were able to efficiently fucosylate a wide variety of complex N-glycopeptides and intact glycoproteins. The site specific mutants enable the transfer of fucose to a core GlcNAc-Asn residue and useful for drug delivery and vaccine development.
Thomson Reuters - Z-Park, Haidian District, Beijing since Sep 2011
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Guillaume Vignal School Brossard Kuwait 1993-1997, La Mennais High School La Prairie Kuwait 1997-2002, River of Meadows High School Montreal Kuwait 1998-2002