Chao Gen Lin

US Patent:

6379883, Apr 30, 2002

Filed:

Dec 21, 2000

Appl. No.:

09/741347

Inventors:

Graham Davis - Princeton NJ
Chao Lin - Monmouth Junction NJ
Imants R. Lauks - Rockcliffe Park, CA
Raymond J. Pierce - Ottawa, CA

Assignee:

i-STAT Corporation - East Windsor NJ

International Classification:

C12Q 100

US Classification:

435 4, 435 11, 435 14, 435 25, 4352871, 4352878

Abstract:

A chemical sensor includes an enzyme layer, a diffusion layer and an analyte barrier layer positioned over the diffusion layer. Apertures are formed by microfabrication in the analyte barrier layer to allow controlled analyte flux to the diffusion layer.

US Patent:

6485690, Nov 26, 2002

Filed:

May 27, 1999

Appl. No.:

09/321410

Inventors:

Dale R. Pfost - Pennington NJ
Sheila H. DeWitt - Stockton NJ
Chao Lin - Monmouth Junction NJ
Rolf E. Swenson - Princeton NJ
Robert D. Juncosa - Yardley PA
Gary J. Schnerr - Pennington NJ
Sheldon M. Kugelmass - New York NY

Assignee:

Orchid BioSciences, Inc. - Princeton NJ

International Classification:

B01L 300

US Classification:

422102, 422 681, 422 99, 422100, 436174, 436179, 436180

Abstract:

Multiple fluid sample processors and systems for high throughput chemical synthesis and biological assays and/or processing. A multi-layered fluidic array having microchannels, reservoirs and reaction wells is subject to robotic and automated handling. A pressure pumping system is utilized for fluid delivery and control through the synthesis process. The sizes of the micro-sized channels, apertures, and valves are adjusted to optimize fluid distribution and channel filling. The fluid sample processors can be grouped together in a microtiter format to increase the speed, quantity and efficiency of the processing.

US Patent:

7419821, Sep 2, 2008

Filed:

Mar 5, 2002

Appl. No.:

10/087730

Inventors:

Graham Davis - Princeton NJ, US
Imants R. Lauks - Ottawa, CA
Chao Lin - San Diego CA, US
Cary James Miller - Ottawa, CA

Assignee:

I-Stat Corporation - East Windsor NJ

International Classification:

C12M 3/00

US Classification:

4352885, 435 71, 4352831, 4352852, 4352871, 4352872, 436518, 422 50, 422 81, 422 8201

Abstract:

The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.

US Patent:

8017382, Sep 13, 2011

Filed:

Jul 1, 2008

Appl. No.:

12/165925

Inventors:

Graham Davis - Princeton NJ, US
Imants R. Lauks - Ottawa, CA
Chao Lin - San Diego CA, US
Cary James Miller - Ottawa, CA

Assignee:

Abbott Point of Care Inc. - Princeton NJ

International Classification:

C12M 3/00

US Classification:

4352885, 435 71, 4352831, 4352852, 4352871, 4352872, 436518, 422 50, 422 81, 422 8201

Abstract:

The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.

US Patent:

8222024, Jul 17, 2012

Filed:

Aug 4, 2011

Appl. No.:

13/198253

Inventors:

Graham Davis - Princeton NJ, US
Imants Lauks - Ottawa, CA
Chao Lin - San Diego CA, US
Cary James Miller - Ottawa, CA

Assignee:

Abbott Point of Care Inc. - Princeton NJ

International Classification:

C12M 3/00

US Classification:

4352885, 435 71, 4352831, 4352852, 4352871, 4352872, 436518, 422 50, 422 81, 422 8201

Abstract:

The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.

US Patent:

20120305409, Dec 6, 2012

Filed:

Jun 13, 2012

Appl. No.:

13/495224

Inventors:

Graham Davis - Princeton NJ, US
Imants R. Lauks - Ottawa, CA
Chao Lin - San Diego CA, US
Cary James Miller - Ottawa, CA

Assignee:

ABBOTT POINT OF CARE INC. - Princeton NJ

International Classification:

G01N 27/26

US Classification:

2057775

Abstract:

The present invention relates to methods for measuring an amount of an analyte using an electrochemical assay in a conduit comprising a sensor, wherein said sensor comprises an electrode having a surface layer of immobilized antibody that binds said analyte, and a counter/reference electrode disposed within said conduit. A solution comprising a substrate for said enzyme and at least one air segment contacts the sensor to remove unbound analyte and labeled antibody from a region of the sensor. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.

US Patent:

60308273, Feb 29, 2000

Filed:

Jan 23, 1998

Appl. No.:

9/012579

Inventors:

Graham Davis - Princeton NJ
Chao Lin - Monmouth Junction NJ
Imants R. Lauks - Rockcliffe Park, CA
Raymond J. Pierce - Ottawa, CA

Assignee:

i-Stat Corporation - East Windsor NJ

International Classification:

C12M 140

US Classification:

4352871

Abstract:

A chemical sensor includes an enzyme layer, a diffusion layer and an analyte barrier layer positioned over the diffusion layer. Apertures are formed by microfabrication in the analyte barrier layer to allow controlled analyte flux to the diffusion layer.