Charles E Ingram

US Patent:

20130039147, Feb 14, 2013

Filed:

Jan 25, 2011

Appl. No.:

13/517942

Inventors:

Russell S. Witte - Tucson AZ, US
Leonardo Gabriel Montilla - Tucson AZ, US
Ragnar Olafsson - Tucson AZ, US
Charles M. Ingram - Tucson AZ, US
Zhaohui Wang - Tucson AZ, US
Robert A. Norwood - Tucson AZ, US
Charles Greenlee - Tucson AZ, US

International Classification:

G01S 15/89
G01N 29/24
G01N 21/17

US Classification:

367 7, 367140

Abstract:

Devices are disclosed for obtaining data of a sample, particularly data capable of being processed to produce an image of a region of the sample. An exemplary device includes a light-beam source, an acoustic-wave source, an optical element, and an acoustic detector. The optical element is transmissive to a light beam produced by the light-beam source and reflective to acoustic waves produced by the acoustic-wave source. The optical element is situated to direct the transmitted light beam and reflected acoustic wave simultaneously along an optical axis to be incident at a situs in or on a sample to cause the sample to produce acoustic echoes from the incident acoustic waves while also producing photoacoustic waves from the incident light beam photoacoustically interacting with the situs. The acoustic detector is placed to receive and detect the acoustic echoes and the photoacoustic waves from the situs. The acoustic detector can comprise one or more hydrophones exploiting the acousto-electric effect.

US Patent:

20210068753, Mar 11, 2021

Filed:

Sep 7, 2018

Appl. No.:

16/644853

Inventors:

- Tucson AZ, US
Yexian Qin - Tucson AZ, US
Charles Ingram - Tucson AZ, US
Alex Burton - Tucson AZ, US
Russell S. Witte - Tucson AZ, US

International Classification:

A61B 5/00
A61B 5/06

Abstract:

Acoustoelectric imaging (AEI) offers a novel, non-invasive method for monitoring current densities produced by a deep brain stimulator (DB S) or other medical device. By providing visual feedback of the electrical current patterns produced by the device, AEI may help guide placement of an implant during surgery, monitor device performance during routine checkups and over time, and perform accurate calibrations (in vivo or in situ).

US Patent:

20210059535, Mar 4, 2021

Filed:

Sep 7, 2018

Appl. No.:

16/644755

Inventors:

- TUCSON AZ, US
Yexian Qin - Tucson AZ, US
Matthew O'Donnell - Seattle WA, US
Zhen Xu - Ann Arbor MI, US
Charles Ingram - Tucson AZ, US

International Classification:

A61B 5/00
A61B 8/00
A61B 8/08
A61B 8/06
G01S 15/89
G01S 7/52

Abstract:

A two-dimensional wideband ultrasound transducer array for three or four-dimensional (volume+time) non-invasively imaging/mapping of electrical current in, for example, the brain through the skull, or the heart. The probe also has unique capabilities for three-dimensional transcranial or transthoracic pulse echo ultrasound (tissue structure, motion, bone thickness) and doppler blood flow imaging. The handheld device interfaces with an ultrasound delivery system for applications to human brain or heart imaging, ultrasound neuromodulation, and therapy. The handheld ultrasound array enables three-dimensional steering of an ultrasound beam through the human skull or chest for ultrasound, doppler, and acoustoelectric imaging and related modalities to aid in the diagnosis and treatment of brain or heart disorders.

US Patent:

20190307333, Oct 10, 2019

Filed:

Jun 5, 2017

Appl. No.:

16/306664

Inventors:

- Tucson AZ, US
Charles M. INGRAM - Tucson AZ, US
Qian LI - Tucson AZ, US
Yexian QIN - Tucson AZ, US

Assignee:

Arizona Board of Regents on Behalf of the University of Arizona - Tucson AZ

International Classification:

A61B 5/00
A61B 18/02
A61B 18/08
A61B 18/12
A61N 7/02

Abstract:

An acoustoelectric image-guided therapy system and method for applying acoustoelectric image-guided therapy are disclosed. Embodiments are directed to therapy systems and methods that utilize and are based on acoustoelectric imaging. The acoustoelectric imaging may be combined with focused therapies such as ultrasound, ablation, or hyperthermia for treatment of, for example, acute or chronic conduction abnormalities (e.g., neuropathy, arrhythmia, epilepsy, etc.). Current-density maps are obtained near the region of interest using acoustoelectric imaging techniques. Targeting of the region of interest is then identified for therapy based on the current-density maps. Treatment of the targeted region of interest is then employed while optionally monitoring bioelectric properties using real-time feedback from the acoustoelectric imaging. Imaging and therapy may be automatically co-registered. Standard electrophysiology (e.g., ENG, ECG, EEG, etc.) may be performed simultaneously with the same electrodes used for the acoustoelectric imaging.

US Patent:

20150226845, Aug 13, 2015

Filed:

Nov 4, 2014

Appl. No.:

14/533013

Inventors:

- Tucson AZ, US
Leonardo Gabriel Montilla - Tucson AZ, US
Ragnar Olafsson - Tucson AZ, US
Charles M. Ingram - Tucson AZ, US
Zhaohui Wang - Tucson AZ, US
Robert A. Norwood - Tucson AZ, US
Charles Greenlee - Tucson AZ, US

International Classification:

G01S 7/52
A61B 5/00
G01S 15/02

Abstract:

Devices are disclosed for obtaining data of a sample, particularly data capable of being processed to produce an image of a region of the sample. An exemplary device includes a light-beam source, an acoustic-wave source, an optical element, and an acoustic detector. The optical element is transmissive to a light beam produced by the light-beam source and reflective to acoustic waves produced by the acoustic-wave source. The optical element is situated to direct the transmitted light beam and reflected acoustic wave simultaneously along an optical axis to be incident at a situs in or on a sample to cause the sample to produce acoustic echoes from the incident acoustic waves while also producing photoacoustic waves from the incident light beam photoacoustically interacting with the situs. The acoustic detector is placed to receive and detect the acoustic echoes and the photoacoustic waves from the situs. The acoustic detector can comprise one or more hydrophones exploiting the acousto-electric effect.